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初诊2型糖尿病患者血清betatrophin水平及其与胰岛素抵抗水平的关系 被引量：7

The relationship between serum betatrophin levels of newly diagnosed type 2 diabetes patients and insulin resistance
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摘要 目的探讨初诊2型糖尿病患者血清betatrophin水平及其与胰岛素抵抗水平的关系。方法选择31例健康体检者作为对照组,初诊未经治疗的2型糖尿病患者35例作为初诊T2DM组,采用ELISA法测定betatrophin含量,应用稳态模型评估法计算胰岛素抵抗指数(HOMA-IR)。结果 B组betatrophin、游离脂肪酸、HOMA-IR、空腹血糖、空腹胰岛素、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇高于A组(P<0.05)。结论胰岛素抵抗导致初诊2型糖尿病患者血清betatrophin水平升高。 Objective To investigate the association between serum betatrophin levels and insulin resistance in newly diagnosed type 2 diabetes patients. Methods A total of 31 healthy subjects （control group） and 35 newly-diagnosed type 2 diabetes patients（new T2DM group） were recruited. Serum betatrophin was detected with the methods of ELISA, insulin resistance was assessed with homeostasis model（HOMA-IR）. Results The levels of betatrophin, free fatty acids, HOMA-IR, fasting plasma glucose, fasting serum insulin, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were significantly higher in group B than those in group A （P〈0.05）. Conclusion Insulin resis-tance leads to elevated serum levels of betatrophin in patients with newly diagnosed type 2 diabetes.
作者 王韵阳 张迪 董静 蒋正尧 鲁晓晴 王颜刚
机构地区 青岛大学临床医学院 青岛大学附属医院内分泌与代谢病科 青岛大学医学院特种医学与装备研究所 青岛大学医学院生理学教研室 青岛大学公共卫生学院
出处 《中国现代医生》 2015年第3期4-6,共3页 China Modern Doctor
基金 国家自然科学基金(31371168)
关键词 2型糖尿病 betatrophin蛋白 胰岛素抵抗 甘油三酯 游离脂肪酸 Type 2 diabetes Betatrophin Insulin resistance Triglyceride Free fatty acids
分类号 R587.1 [医药卫生—内分泌]
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参考文献16

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共引文献288

同被引文献41

  • 1陈宋明,李玉光,王东明,卢成志.冠心病患者外周血白细胞血红素氧合酶1的表达与冠状动脉病变程度有关[J].中国动脉硬化杂志,2004,12(5):581-584. 被引量：8
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  • 6侯保俊,胡勇.中青年冠心病的临床及流行病学研究[J].中华高血压杂志,2015,23(3):111.
  • 7Mattijssen F, Kersten S. Rugulation of triglyceride metabolism by Angiopoietiulike proteins[ J ]. Biochim Biophys Acta, 2012,1821 (5) :782-789.
  • 8Fu Z, Berhance F, Fite A, et al. Elevated circulating lipasin/Be- tatrophin in human type 2 diabetes and obesity[J]. Sci Rep, 2014 (4) :5013.
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引证文献7

二级引证文献18

中国现代医生
2015年 第3期

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