肿瘤深部热疗联合羟考酮缓释片治疗骨转移癌痛的临床疗效观察

The clinical efficacy of tumor deep hyperthermia combined with oxycodone sustained-release tablets in the treatment of bone metastasis of cancer pain

目的肿瘤深部热疗联合羟考酮缓释片治疗骨转移癌痛临床效果以及安全性研究。方法将在我院确诊的120例骨转移癌患者随机分为实验组和对照组,实验组给予肿瘤深部热疗联合羟考酮缓释片治疗,对照组给予羟考酮缓释片口服治疗。观察每天吗啡缓释片用药剂量情况、骨转移癌痛每天爆发痛次数、每天生活质量评分(Karnofsky评分)、疼痛缓解率以及不良反应状况。结果实验组患者治疗后Karnofsky行为状况评分为(60.72±6.08)分,而对照组为(30.37±5.31)分,明显低于实验组,差异具有统计学意义(P<0.05);治疗前两组每天骨转移癌痛爆发痛次数大致相当。随着病情进展,治疗第7天与治疗前比较,骨转移癌痛爆发痛次数实验组没有变化,对照组增加,两组比较差异有显著性(P<0.05);第14天两组骨转移癌痛爆发痛次数均增加,但实验组爆发痛增加次数较对照组少,差异有显著性(P<0.05);实验组患者经治疗后的总有效率65.08%明显大于对照组(19.30%)(P<0.05)。两组患者的不良反应无明显差异(P>0.05)。结论肿瘤深部热疗联合羟考酮缓释片治疗骨转移癌痛的临床疗效显著,有效改善患者的生活质量,其过程中副作用小,值得在临床推广。

Objective To explore the clinical efficacy and security of tumor deep hyperthermia combined with oxy-codone sustained-release tablets in the treatment of bone metastasis of cancer pain. Methods All 120 cases of bone metastasis of cancer patients diagnosed in our hospital were randomly divided into two group. The experimental group received tumor deep hyperthermia combined with oxycodone sustained-release tablets treatment ,and the control group was given oxycodone sustained-release tablets for treatment.And observe Karnofsky behavior score ,pain relief rate and adverse reaction conditions of two groups. Results After treatment,the experiment group’s Karnofsky behavior score was （60.72±6.08）,and the control group’s Karnofsky behavior score was （30.37±5.31）,which was significantly lower than the experiment group,the difference was statistically significant （P〈0.05）;the total efficiency of the experimental group of patients after treatment （65.08%） was significantly greater than the control group of patients with total efficiency （19.30%）,there was statistically significant difference （P〈0.05）. The adverse reactions indexing of two groups pa-tients had no significant difference （P〉0.05）. Conclusion The clinical efficacy of tumor deep hyperthermia combined with sustained-release oxycodone tablets in the treatment of bone metastases of cancer pain is significantly ,which can improve the quality of life of patients, their process of side effects,so it is worth of promotion in clinic.