低频重复经颅磁刺激对帕金森病患者功能障碍及抑郁症状的影响

Effect of low frequency repetitive transcranial magnetic stimulation on dysfunction and depressive symptoms of parkinson disease patients

目的探讨低频重复经颅磁刺激对帕金森病患者功能障碍和抑郁情绪的治疗效果。方法 50例帕金森病患者采用随机数字表法分为观察组和对照组,每组25例;对照组给予常规药物和康复训练,观察组在对照组的基础上给予低频重复经颅磁刺激治疗。结果治疗1个月后,观察组的UPDRSⅠ、UPDRSⅡ、UPDRSⅢ评分、UPDRS总分均低于对照组,差异有统计学意义(P<0.05)。观察组的MMSE评分与对照组比较,差异无统计学意义(P>0.05),但观察组的HAMD评分低于对照组,差异有统计学意义(P<0.05)。结论低频重复经颅磁刺激可作为一项无创性物理治疗帕金森病的措施。

Objective To discuss the clinical effect of transcranial magnetic stimulation in treatment of dysfunction and depression of parkinson disease patients. Methods A totao of 50 cases of parkinson patients were randomly divided into the observation group and the control group, each group 25 cases, the control group was given conventional medicine and rehabilitation training, the observation group was given low frequency repetitive transcranial magnetic stimulation based on the control group. Results After 1 months of treatment, UPDRS Ⅰ, UPDRS II, UPDRS III, UP-DRS total scores in the observation group were lower than that in the control group, there was statistical significance （P〈0.05）. Compared MMSE scores between the observation group and the control group, there was no statistical sig-nificance （P〉0.05）, but HAMD score in the observation group was lower than that in the control group, there was statis-tical significance （P〈0.05）. Conclusion Low frequency repetitive transcranial magnetic stimulation can be used as a non-invasive measure of physical therapy for parkinson＆#39;s disease.