吖啶酮衍生物作为增强型荧光信号探针用于8-羟基喹啉铜的检测

Acridone Derivatives as an Enhanced Fluorescent Signal Probe for Detection of 8-hydroxyquinoline Copper

[目的]建立一种检测8-羟基喹啉铜的方法。[方法]采用自制合成的吖啶酮衍生物10-甲基-3-硝基一吖啶酮（MAT）作为增强型荧光信号探针，建立8-羟基喹啉铜的测定方法。[结果]在最佳条件下荧光增强值与8-羟基喹啉铜的浓度在5×10^-9-5×10^-5mol/L范围内成良好的线性关系，检测限为6×10^-10mol／L。[结论]该方法灵敏度高、检测范围宽，结果令人满意，可用于实际样品中8-羟基喹啉铜含量的直接测定。

[ Objective] The aim was to establish a detection method for 8-hydroxyquinoline Copper. [ Method] Using the self-made acridone derivative lO-methyl-3-nitro-aeridone （MAT） as an enhanced fluorescence signal probe, a method for determination of 8-hydroxyquinoline copper was established. [ Result] Under the optimal conditions, the value of fluorescence enhancement showed a good linear relationship with the concentration of 8-hydroxyquinoline copper in the range of 5 × 10^-9 to 5 ×10^-5 mol/L, and the detection limit was 6 × 10^-10 mol/L. [ Conclusion] The method has high sensitivity and wide detection range, so it can be used for direct determination of 8-hydroxyquinoline copper in real samples with satisfactory resuhs. Key words 8-hydroxyquinoline copper ; MAT; Fluorescence ; Enhanced