六味地黄丸与干预生活方式治疗糖耐量异常随机平行对照研究

The Six Tastes Glutinous Rehmannia Pill in the Treatment of Abnormal Glucose Tolerance Random Parallel Controlled Study

[目的]观察六味地黄丸与生活方式干预治疗糖耐量异常疗效。[方法]使用随机平行对照方法,将80例门诊患者按病志号按抽签方法随机分为两组。对照组40例干预生活方式,戒烟戒酒,严格按糖尿病饮食。治疗组40例六味地黄丸(北京同仁堂,120g/瓶),6g/次,2次/d;干预生活方式同对照组。连续治疗干预1年为1疗程。观测临床症状、空腹血糖、糖负荷后2h血浆血糖、总胆固醇、甘油三酯、临床转归、不良反应,治疗干预1疗程,判定疗效。[结果]治疗组显效34例,有效5例,无效1例,总有效率97.50%;对照组显效2例,有效3例,无效35例,总有效率12.50%;治疗组疗效优于对照组(P<0.05)。FBG、2h PBG均明显下降(P<0.05),治疗组下降优于对照组(P<0.05);TC、TG均明显下降(P<0.05),组间无明显差异(P>0.05)。对照组糖耐量转为正常2例(5%),仍为IGT 29例(72.5%),转为DM 9例(22.5%),DM年转率22.5%;六味地黄丸组糖耐量转为正常27例(67.5%),仍为IGT11例(27.5%),转为DM2例(5%),DM平均年转率为5%;DM平均年转率治疗组低于对照组(P<0.05),发生DM危险对照组是六味地黄丸组的4.5倍(OR=4.5)。[结论]六味地黄丸与干预生活方式治疗糖耐量异常,疗效满意,无副作用,值得推广。

[ Objective ] To observe the intervention of Six Ingredient Rehmannia Pill and lifestyle effect the treatment of abnormal glucose tolerance amount. [ Method ] Using random parallel control method, 80 cases outpatients Zhihao by lottery method were randomly divided into two groups. A control group of 40 cases of lifestyle intervention, smoking and drinking, in strict accordance with the diabetic diet. The treatment group 40 cases of Six Ingredient Rehmannia Pill （Beijing Tongrentang, 120g/ bottle）, 6g/ times, 2 times /d; lifestyle intervention with control group. Continuous treatment intervention for 1 years to 1 course of treatment. Observation of clinical symptoms, fasting blood glucose, glucose load after 2H plasma glucose, total cholesterol, triglyceride, clinical outcome, adverse reactions, treatment and intervention of 1 period of treatment, curative effect. 34 cases of the treatment group produce [ Results ] Effective 5 cases, invalid 1 cases, the total efficiency of 97.50%; control group 2 cases were markedly effective, effective 3 cases, invalid 35 cases, the total efficiency of 12.50%; the efficacy of the treatment group was better than that of the control group （P 〈 0.05）. FBG and 2hPBG were significantly decreased （P 〈 0.05）, the treatment group decreased than that of the control group （P 〈 0.05）; TC and TG were significantly decreased （P 〈 0.05）, no significant difference between groups （P 〉 0.05）. The control group of glucose tolerance to normal in 2 cases （5%）, is IGT in 29 cases （72.5%）, to DM in 9 cases （22.5%）, DM conversion rate is 22.5%; the six tastes glutinous rehmannia pill group glucose tolerance to normal in 27 cases （67.5%）, is IGT11 cases （27.5%）, turn for DM2 cases （5%）, DM average annual turn rate of 5%; annual average DM transfer rate in the treatment group than in the control group （P 〈 0.05）, the occurrence of DM risk control group is 4.5 times the six tastes glutinous rehmannia pill group （OR=4.5）. [ Conclusion ] The six tastes glutinous rehmannia pill with lifestyle intervention for the treatment of abnormal glucose tolerance, satisfactory curative effect, no side effect, is worth promoting.