小柴胡汤合平胃散治疗胃食管反流随机平行对照研究

Gastroesophageal Reflux Randomized Parallel Group Study Xiaochaihutang Pingwei Treatment

[目的]观察小柴胡汤合平胃散治疗胃食管反流疗效。[方法]使用随机平行对照方法,将65例住院患者按病志号抽签法简单随机分为两组。对照组30例兰索拉唑,20mg/次,2次/d,饭前口服;莫沙比利,10mg/次,3次/d,饭前口服;磷酸铝,20g/次,3次/d,饭前口服。治疗组35例小柴胡汤合平胃散(柴胡15g,黄芩、制半夏各10g,党参12g,苍术6g,厚朴9g,陈皮6g,甘草5g,九节茶20g,蒲公英15g,郁金10g;热甚口苦、口干加黄连、白花蛇舌草、栀子;腹胀甚加枳实、香附;纳呆加麦芽炒、谷芽、莱菔子;久病不愈舌底脉络青紫瘀曲加丹参、檀香、砂仁),1剂/d,水煎300m L,餐前30min早晚口服。连续治疗56d为1疗程。观测临床症状、食管黏膜、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈18例,显效11例,有效4例,无效2例,总有效率94.28%。对照组痊愈10例,显效8例,有效4例,无效8例,总有效率71.33%。治疗组疗效优于对照组(P<0.05)。[结论]小柴胡汤合平胃散治疗胃食管反流效果显著,值得推广。

[ Objective ] To observe Xiaochaihutang Pingwei treatment of gastroesophageal reflux efficacy. [ Methods ] using random parallel control method, 65 cases of hospitalized patients by disease Zhi No. ballot method is simple and randomized into two groups. The control group 30 cases lansoprazole, 20mg / times, 2 times / d, orally before meals; Mosapride, 10mg / times, 3 times / d, orally before meals; aluminum phosphate, 20g / time, 3 times / d, orally before meals. 35 cases treated Xiaochaihutang Pingwei （Chaihu15g, Huangqi,Zhibanxia 10g, Dangshen12g, Cangzhu 6g, Houpu 9g, Chengpi 6g, Gancao 5g, Jiujiecha 20g, Pugongying 15g, Yujin 10g; thermal even mouth pain, dry mouth plusHuanglian,Baihuasheshecao,Zhizi; bloating even add citrus Zhishi,Xiangfu; anorexia plusChaomaiya,Guya,Laifuzi; chronic illness is not becoming increasingly tongue context bruising stasis Danshen,Tanxiang,Sharen）, a/d, decoction 300mL, sooner or later orally 30min before a meal. 56d is a continuous course of treatment. Observation of clinical symptoms and esophageal mucosa, adverse reactions. A course of treatment to determine efficacy. [ Results ] The cure 18 cases, effective in 11 cases, effective in 4 cases, 2 cases, the total efficiency of 94.28%. Cured 10 cases in the control group, eight cases markedly effective in 4 cases, 8 cases, the total efficiency of 71.33%. Treatment group than the control group （P〈0.05）. [ Conclusion ] Xiaochaihutang Pingwei treatment of gastroesophageal reflux effect is significant, it is worth promoting.