金水宝联合依那普利治疗糖尿病肾病随机平行对照研究

Randomized Parallel Controlled Study Jinshui Bao and Enalapril in the Treatment of Diabetic Nephropathy

[目的]观察金水宝联合依那普利治疗糖尿病肾病疗效。[方法]使用随机平行对照方法,将44例门诊患者按随机数字表法随机分为两组。对照组22例依那普利,10mg/次,1次/d,口服。治疗组22例金水宝,3粒/次,3次/d、口服依那普利治疗同对照组。治疗30d为1疗程。观测临床症状、24h尿微量白蛋白、血糖、血压、血常规、血生化、肝功能、不良反应。连续治疗3个疗程,判定疗效。[结果]治疗组显效11例,有效10例,无效1例,总有效率95.45%。对照组显效5例,有效6例,无效11例,总有效率50.00%。治疗组疗效优于对照组(P<0.05)。治疗前、后24h尿微量白蛋白治疗组优于对照组(P<0.05)。[结论]金水宝联合依那普利治疗糖尿病肾病效果显著,值得推广。

[ Objective ] To observe the curative effect of Jinshui treasure and enalapril in the treatment of diabetic nephropathy. [ Method ] Using random parallel control method, 44 cases of outpatients were randomly divided into two groups. The control group of 22 cases with enalapril, 10mg/, 1/d, oral. The treatment group of 22 eases of Jinshui Bao, 3 capsules each time, 3 times/d, enalapril treatment with the control group. For the 1 course of treatment of 30D. Observation of clinical symptoms, 24h urinary albumin, blood glucose, blood pressure, blood routine test, blood biochemistry, liver function, adverse reaction. Continuous treatment of 3 courses of treatment, curative effect. 11 cases of the treatment group produce [ Results ] Effective 10 cases, invalid 1 cases, the total efficiency of 95.45%. The control group was 5 cases, effective 6 cases, invalid 11 cases, the total efficiency of 50%. The efficacy of the treatment group was better than that of the control group （ P 〈 0.05 ） . Before and after treatment, urine micro albumin in 24h treatment group than in control group （ P 〈 0.05 ） . [ Conclusion ] Jinshui Bao combined with enalapril in treatment of diabetic nephropathy with significant effect, worthy of promotion.