首发抑郁症患者血清同型半胱氨酸水平、P300的相关研究

Correlation between Serum Homocysteine Level and P300 in Patients with First-episode Depression

目的:研究首发抑郁症患者血清同型半胱氨酸(Homocysteine,Hcy)与事件相关电位P300之间的关系。方法:采用脑诱发电位仪对48例首发抑郁症患者及46名正常对照进行P300测查,荧光偏振免疫法(FPLA)测定血清同型半胱氨酸浓度。结果:研究组血清Hcy水平高于对照组,差异有统计学意义(P<0.01)。与对照组比较,研究组P300中P3波幅明显降低(P<0.01)。相关分析显示,研究组血清Hcy水平与P3波幅呈负相关(r=-0.295,P<0.05),而与N2潜伏期呈正相关(r=0.354,P<0.05)。结论:血清Hcy检测联合P300测查可以作为筛查首发抑郁症的生物学指标。

Objective To investigate the correlation between the serum level of homocysteine （Hey） and P300 in patients with first-episode depression. Methods P300 was tested by the brain evoked potentiometer and the serum level of Hcy was measured by fluorescence polarization immunoassay（FPLA）. Results The serum level of Hcy in observation group was significantly higher than that in control group（P 〈0.01 ） ,but the P3 amplitude of P300 in observation group was significantly decreased compared with control group（ P 〈 0. 01 ）. Furthermore, the serum level of Hcy was negatively correlated with P3 amplitude （ r = 0. 295, P 〈 0.05 ） and positively correlated with N2 latency period （ r = 0.354, P 〈 0. 05 ） in patients with first-episode depression. Conclusion The serum level of Hcy combined with P300 could be used as biological markers of patients with first-episode depression.