微流体脉冲惯性驱动-控制用T型玻璃微喷嘴设计及实验

Design and experiment of T-shape glass micro-nozzle used in pulse driving-controlling of micro-fluids

为了简化用于微流体脉冲惯性驱动-控制的T型玻璃微喷嘴的制作工艺,设计制作了重力式玻璃微喷嘴制作仪、微孔制作仪。研究了拉力、线圈温度、延时时间、线圈宽度对拉制工艺,加热时间、进给量对锻制工艺,加热面积对微孔制作工艺的影响规律。制作了微喷嘴、微管道、玻璃微孔等基本微流体器件并以紫外线(UV)光学胶水密封组合,设计制作了T型玻璃微喷嘴。设计了拉锻集成式玻璃微流体器件制作设备,其拉制工艺延时控制结构比非延时控制结构制作的微喷嘴锥长可减小3.5 mm。微孔制作仪可在玻璃毛细管侧壁开制400μm圆形微孔。制作了序列玉米胚芽油海藻酸钠水油(W-O)乳液和500μm左右的单、双颗玉米胚芽油微胶囊,其粒径均匀、形态良好。结果表明,基于冷热加工工艺及组合工艺可以制作结构简单、生物化学性能和光学性能良好的T型组合玻璃微流体器件,基于脉冲惯性驱动可以产生多相流体脉冲流动及微喷射。

In order to simplify the fabrication process of T-shape glass micro-nozzles used in pulse driving-controlling of micro-fluids, a novel gravity based glass micro-nozzle preparation apparatus and a micro hole fabrication apparatus are designed and fabricated. The impact laws of pull force, coil temperature ,delay time, coil width on pulling process, heating time, feed distance on forging process,and heating area on micro hole fabrication process are researched experimentally. Borosilicate glass microfluidic devices such as miero-nozzle, micro-channel, miero hole in the glass capillary wall are prepared. Sealed by ultraviolet rays（UV） optical glue ,a kind of T-shape glass micro-nozzle is designed and prepared. A glass microfluidic device preparation apparatus integrating forging and pulling process is designed. The tape length of the micro-nozzle fabricated by the pulling process with delay control structure is 3.5 mm shorter than that fabricated by the pulling process without delay control structure. 400 μm circular micro holes can be fabricated on the glass pipe wall by the micro hole fabrication ap- paratus. Orderly core oil emulsion in sodium alginate solution and 500 μm microcapsules with single or double core oil are prepared uniformly and well. Results show that T-shape combined glass microfluidic devices could be fabricated by hot-cold fabricating process and have the advantage of simple structure, low cost, good bio-chemical and optical characters, and the T-shape glass micro-nozzle driven by pulse inertia force could be used to prepare pulse fluid flow and micro injection.