中西医结合治疗早期帕金森病患者运动症状的随访研究

Follow-up research of integrated Chinese and Western medicines in the treatment of motor symptoms in patients with early Parkinson's disease

目的探讨中西医结合治疗早期帕金森病患者运动症状的有效性。方法 38例早期帕金森病患者随机分为治疗组和对照组。治疗组19例患者常规给予金刚烷胺片治疗的基础上,内服平肝止颤汤治疗4周,对照组19例患者单纯给予金刚烷胺片治疗。观察两组治疗疗效。结果治疗组治疗后4周运动症状的改善与对照组比较差异有统计学意义(P<0.05),4周后停服中药,随访至12周治疗组运动症状评分优于对照组(P<0.05)。结论中西医结合治疗早期帕金森病可更好地改善患者运动症状,提高疗效。

Objective To investigate the effectiveness of integrated Chinese and Western medicines in the treatment of motor symptoms in patients with early Parkinson＇s disease. Methods A total of 38 patients with early Parkinson＇s disease were randomly divided into treatment group and control group. The treatment group with 19 cases received oral Pinggan Zhichan decoction for 4 weeks, in addition to conventional amantadine tablets treatment. The control group was treated by single therapy of amantadine tablets. The curative effects of the two groups were observed. Results After 4-week treatment, there was statistically significant difference of improved ＂motor symptoms between the treatment group and control group （P〈0.05）. The traditional Chinese medicine was withdrawn after 4 weeks, and the treatment group had higher scores of motor symptoms in 12 weeks of follow-up than the control group （P〈0.05）. Conclusion The application of integrated Chinese and Western medicines can remarkably improve patients＇ motor symptoms, and enhance curative effect.