Synthesis, separation and NMR analysis of geometrical isomers of 3-benzylidene-indolin-2-one derivatives

3-苯亚甲基-2-吲哚酮衍生物几何异构体的合成分离与NMR分析(英文)

A series of E and Z-isomers of 3-（4＇-substituted benzylidene）-indolin-2-one derivatives were synthesized and separated. Based on their 1H NMR characterization, an unusual counterintuitive deshielding phenomenon for the protons presenting in the shielding zone of phenyl ring was observed and analyzed for the first time.

本文合成了一系列3-(4'-取代苯亚甲基)-2-吲哚酮的E和Z几何异构体,并采用反相硅胶色谱的方法首次对所有异构体进行了成功分离。通过对E和Z异构体1H NMR特征的分析发现了E和Z异构体中处于取代苯环屏蔽区的质子实际受到较明显去屏蔽效应的反常现象并对这种现象进行了分析。