某化纤厂接触不同浓度二硫化碳的工人血糖血脂检出水平

Blood Glucose and Lipid Levels in Workers Exposed to Different Concentrations of Carbon Disulfide in a Chemical Fiber Factory

[目的]研究二硫化碳（cs2）暴露对作业工人血糖（glucose，GLU）、总胆固醇（total cholesterol，TCHO）和三酰甘油（triglyceride，TG）检出水平的影响，并提出职业健康监护行动水平的建议。[方法]收集某化纤厂2004-2011年间工作场所cs2浓度或作业工人个体接触cs2浓度的检测资料，对该化纤厂3456名接触csz的作业工人分别进行GLU、TCHO和TG水平的检查。[结果]该化纤厂作业工人接触cs2的8h时间加权平均浓度为0．2—41．0ms／m3，几何均数为2．38mg／m3。其中1758名作业工人接触CS2的浓度在0．2—2．5ms／m。之间（A组）；653名作业工人接触cs2的浓度在2．6～4．8ms／m。之间（B组）；1045名作业工人接触csz的浓度在5．1～41．0mg／m3之间（c组）。男性C浓度组高TG检出率高于A、B两浓度组，差异有统计学意义（P〈0．05）；A、B浓度组之间差异无统计学意义（P〉0．05）.男性高GLU、高TCHO检出率及女性高GLU、高TCHO和高TG检出率在不同浓度组中差异均无统计学意义（P〉0．05）.各年龄段C浓度组高TG检出率高于A、B两浓度组；A、B浓度组间差异无统计学意义（P〉0．05）.不同浓度组间高GLU和高TCHO检出率差异无统计学意义（P〉0.05）。男性不同累积接触量组问高TG检出率差异有统计学意义（P〈0．01）；高GLU和高TCHO检出率差异无统计学意义（P〉0．05）。女性不同累积接触量组间高GLU、高TCHO和高TG检出率差异无统计学意义（P〉0．05o[结论]男性作业工人接触cs2浓度〉5ms／m。或累积接触量〉50ms／（m3·年）时，可使高TG检出率明显升高。在对cs2作业工人进行职业健康监护时，宜执行cs2时间加权平均浓度为2．5ms／m。（职业接触限值的1，2）的行动水平，并加强对累积接触量〉50mg／（m3·年）的作业工人的健康检查。

[ Objective ] To explore the effects of carbon disulfide on glucose, total cholesterol, and triglyceride levels of workers exposed to carbon disulfide, and make recommendations on the action level of related occupational health surveillance. [ Methods ] Data on concentrations of carbon disulfide in workplace and the exposure levels of workers in a chemical fiber factory were collected from 2004 to 2011. A total of 3 456 workers exposed to carbon disulfide were selected for testing glucose, cholesterol, and triglyceride. Chi-square test was used for statistical analysis. [ Results ] The eight-hour time-weighted aVerage concentrations of the workers exposed to carbon disulfide were 0.2-41.0mg/m3, and the geometric mean was 2.38mg/m3. Specifically, 1758 workers were exposed to carbon disulfide ranging from 0.2 mg/m3 to 2.5 mg/m3 （Group A）, 653 workers were exposed to 2.6-4.8 mg/m3 （Group B）, and 1 045 workers were exposed to 5.1-41.0 mg/m3 （Group C）. For male, the detection rate of elevated triglyceride of Group C was statistically higher than that of Group A or B （P 〈 0.05）, but the difference between group A and group B was not statistically significant （P 〉 0.05）. The differences in the detection rates of elevated glucose and total cholesterol for male and of elevated glucose, total cholesterol, and triglyceride for female were not statistically significant between different concentration groups （P 〉 0.05）. For age groups, the detection rate of elevated total triglyceride of Group C was higher than that of Group A or B （P〈 0.05）, but the difference was not statistically significant between group A and group B （P 〉 0.05）; the difference of the detection rate of elevated glucose and cholesterol between different concentration groups was not statistically significant （P 〉 0.05）. For male, the difference in the detectionrate of elevated triglyceride between different cumulative exposure level groups was statistically significant （P〈 0.01）, but not for the elevated glucose or cholesterol （P 〉 0.05）. For female, the difference in the detection rate of elevated glucose, cholesterol, and triglyceride between different cumulative exposure level groups was not statistically significant （P 〉 0.05）. [ Conclusion ] Carbon disulfide higher than 5 mg/m3 or cumulative exposure higher than 50mg/（m3. year） could elevate the detection rate of total triglyceride in male workers. An action level at 2.5 mg/m3 （time weighed average concentration） is therefore proposed for occupational health surveillance, and those with a cumulative exposure level of carbon disulfide 〉 50 mg/（m3. year） should take strengthened physical exams.