中西医结合卒中单元模式治疗对新疆地区维吾尔族、汉族急性脑梗死患者血清ET-1、TXB_2的影响及临床疗效评价

Effects of integrative treatment model on expressions of ET-1 and TXB_2 of serum in Uyghur and Han patients with acute cerebral infarction in Xinjiang

目的探讨中西医结合卒中单元模式对新疆地区维吾尔族(维族)、汉族急性脑梗死患者血清内皮素1(ET-1)、血栓素B2(TXB2)的影响及临床疗效。方法选择在新疆医科大学附属中医医院住院的维族、汉族急性脑梗死患者400例,随机分为维、汉族对照组和治疗组,每组各100例,取得患者及其家属同意后,治疗组接受中西医结合卒中单元模式治疗,对照组接受常规卒中单元模式治疗。2 w后,比较维、汉族急性脑梗死患者治疗前后卒中量表(NIHSS)评分及血清ET-1、TXB2水平。结果维、汉族急性脑梗死患者治疗组和对照组治疗前后NIHSS评分差异均有统计学意义(P<0.01),维、汉族治疗组与对照组治疗前后NIHSS评分均有统计学意义(P<0.05),维族治疗组与汉族治疗组治疗前后NIHSS评分差比较差异有统计学意义(P<0.05);维、汉族治疗组和对照组治疗前后ET-1含量比较差异有统计学意义(P<0.01),维、汉族治疗组与对照组治疗前后ET-1含量差比较差异有统计学意义(P<0.01),维族治疗组与汉族治疗组治疗前后ET-1含量差比较差异无统计学意义(P>0.05);维、汉族治疗组治疗前后TXB2含量比较差异均有统计学意义(P<0.01),维、汉族对照组治疗前后TXB2含量比较差异均有统计学意义(P<0.05),维、汉族治疗组与对照组治疗前后TXB2含量差比较差异无统计学意义(P>0.05),维、汉族治疗组治疗前后TXB2含量差比较差异无统计学意义(P>0.05)。结论中西医结合卒中单元模式治疗维族、汉族急性脑梗死患者均有较好疗效,维、汉族患者ET-1、TXB2均改善明显,尤其是对维族患者临床疗效更佳。

Objective To observe the effects and clinical significance of integrative treatment model on ET-1 and TXB2 of serum in Uyghur and Han patients with acute cerebral infarction in Xinjiang.Methods 400 cases of Han and Uyghur patients with acute cerebral infarction were selected and grouped：200 Han pa-tients were randomly divided into treatment group and control group,with 100 cases in each group;200 Uyghur patients were randomly divided into treatment group and control group,with 100 cases in each group.The integrative treatment model was applied in the treatment group and the conventional treatment＆amp;nbsp;was applied in the control group.National Institutes of Health Stroke Scale （NIHSS）score,clinical effica-cy and serum ET-1,TXB2 content changes in the pre-treatment and post-treatment in 2 weeks were com-pared and analyzed.Results Two peoples with acute cerebral infarction in treatment group and the control group in pre-treatment and post-treatment had significant difference in NIHSS scores （P 〈0.01）;NIHSS scores in Uyghur treatment group and the control group in pre-treatment and post-treatment differed sig-nificantly （P 〈0.01）;Han treatment group and the control group in pre-treatment and post-treatment had NIHSS score difference （P 〈0.05）;Uyghur and Han treatment group in pre-treatment and post-treatment had NIHSS score difference （P 〈0.05）;ET1 content and ET-1 levels in two treatment and control groups in pre-treatment and post-treatment differed significantly （P 〈0.01）,with no significant difference （P 〉0.05）in Uyghur and Han treatment group in pre-treatment and post-treatment;TXB2 content in two peo-ples had significant difference （P 〈0.01）;TXB2 levels in Uyghur control group and in Han groups had significant differences （P 〈0.01）.Conclusion It proved that the integrative treatment model for Han pa-tients and Uyghur patients with acute cerebral infarction was effective,with obvious improvement in serum ET-1 and TXB2 level,especially for Uyghur patients.