靶向纳米材料在肿瘤诊断和治疗中的研究进展

Research progress of targeted nanomaterials on cancer diagnose and therapy

肿瘤是困扰人类健康的世界难题,当今肿瘤治疗面临的主要问题是不能在肿瘤发生早期做出精确诊断,从而失去治疗的最佳时机,导致肿瘤患者的死亡率逐年增高;此外,肿瘤治疗药物的靶向性差,严重的毒副作用限制了临床应用.因此,设计并开发新型靶向肿瘤的药物载体迫在眉睫.研究表明,靶向纳米材料在肿瘤特异性诊断和治疗方面有极大的优越性.就靶向纳米材料、在肿瘤特异性诊断和靶向治疗方面的研究进展作一综述,并展望其发展前景.

Tumor is still an unresolved health problem for human. The main obstacle for tumor cure is that precise diagnosis of tumor at the early stage can＇t be realized, which leads to the mortality increased year by year due to missing the best time of the treatment. Furthermore, lack of targeted ability and serious side effects of the medicine used for tumor treatment also limit the clinical application. Therefore, it is urgent to design and develop a novel targeted drug delivery vehicle. Recent studies show that targeted nanomaterials are superior on tumor-specific diagnosis and target therapy. This review will highlight the current advances in the targeted nanomaterials effect on tumor diagnosis and treatment in recent years and prospect the foreground of future development.