自身免疫疾病患者全髋关节置换手术前后C反应蛋白、血沉变化的临床意义

Changes in levels of C-reactive protein and erythrocyte sedimentation rate in patients with autoimmune disease before and after total hip arthroplasty

目的探讨自身免性疾病患者行全髋关节置换（THA）术前、后体内C反应蛋白（CRP）和血沉（ESR）变化的临床意义。方法选取72例合并自免性疾病且行THA术的患者为研究对象，分别于术前，术后1、3、7d及术后1个月检测CRP和ESR水平。结果患者术后CRP和ESR显著升高（P〈0．05）。CRP术后3d达到峰值，术后1月与术前相比，差异无统计学意义（P〉0.05）；ESR在术后第7d达峰值，术后1月仍高于术前（P〈0．05）。结论全髋关节置换术后CRP和ESR存在一定的变化趋势，动态监测CRP与ESR有利于自身免疫疾病患者THA术后感染的预防。

Objective To observe the changes in levels of C-reactive protein （CRP） and erythrocyte sedimentation rate （ESR） in patients with autoimmune disease before and after total hip arthroplasty （THA）. Methods A total of 72 patients with autoimmune disease underwent THA, and their levels of CRP and ESR were detected before, 1, 3,7 days and 1 month after surgery. Results After the operation, levels of CRP and ESR were increased （P 〈 0.05 ）. The level of CRP peaked at 3 days after operation, but was no significant difference between preoperation and 1 month after surgery （ P 〉 0.05）. The level of ESR peaked at 7 days after operation, and was significant 1 month after than that before surgery （P 〈 0.05）. Conclusion The levels of CRP and ESR may changes after THA. Dynamic test of CRP and ESR is useful in prevention of infection in patients with autoimmune disease after THA.