地木耳菌粉对2型糖尿病大鼠血糖的影响

Therapeutic Effects of Nostoc commune Powder on Type 2 Diabetic Rats

目的:研究云南野生地木耳粉对2型糖尿病大鼠血糖的影响。方法:采用高脂饲料饲养SD大鼠4周,按35 mg·kg-1腹腔注射给予链脲佐菌素(STZ)诱导2型糖尿病模型。糖尿病模型大鼠随机分为6组,地木耳粉低(25 mg·kg-1)、中(50 mg·kg-1)、高(100 mg·kg-1)剂量组,阳性组(盐酸二甲双胍200 mg·kg-1),模型组(等量生理盐水)和一直用普通饲料喂养的正常组,连续给药6周,检测各组大鼠体重、摄水量、排尿便量及空腹血糖。结果:给药6周后,与模型组比较,高、中、低剂量组大鼠的体质量明显增加,血糖、饮水量及排尿便量明显降低;3个剂量组的体重、摄水量、排尿便量及血糖有显著差异。与阳性组比较,3个剂量组的体重、摄水量、排尿便量及血糖无显著差异。结论:地木耳能缓解STZ致2型糖尿病大鼠症状,具有降低血糖的作用,且效果与地木耳浓度呈正相关。

Objective：To investigate therapeutic effects of Nostoc commune powder on blood glucose of type 2 diabetic rats.Method：Type 2 diabetic rats model was established by intraperitoneal injection of streptozotocin （STZ,35 mg ·kg^-1） on SD rats after rats were fed with high sugar and high fat for 4 weeks.These rats were divided into 6 models,included low dose group （N.commune powder 25 mg ·kg^-1）,middle dose group （N.commune powder 50 mg ·kg^-1）,high dose group （N.commune powder 100 mg ·kg^-1）,positive group （metformin hydrochloride 200 mg ·kg^-1）,model group （physiological saline 200 mg ·kg^-1） and normal group.After 6 weeks of administration,indexes of body weight,fasting blood glucose,total quality of micturition and defecation and water intake were measured.Result：After 6 weeks of administration,compared with the model group,body weight of diabetic rats were significantly increased in low,middle and high dose group,blood glucose and total quality of micturition and defecation,water intake levels of three dose groups of diabetic rats were significantly decreased; these indexes had significant differences among these three dose groups.Effects between positive control groups and three N.commune powder groups were statistically nonsignificant on these four indexes.Conclusion：N.commune powder can reduce blood glucose levels of experimental rats with type 2 diabetes mellitus by intraperitoneal injection of STZ,and effect of hypoglycemic is positively correlated by N.commune powder concentrations.