对肺癌患者检测血清肿瘤标志物的临床价值和意义

Clinical Value of Detection of Serum Tumor Markers in Patients with Lung Cancer

目的：分析血清肿瘤标志物的检测对肺癌临床诊断的价值及意义。方法：选取112例肺癌患者作为研究组，另选取104例肺良性疾病患者作为对照组，两组患者均给予化学发光法进行癌胚抗原（CEA）、糖类抗原19—9（CAl9—9）、糖类抗原125（CAl25）、糖类抗原15—3（CAl5—3）、细胞角蛋白19片段（Cyfra21—1）、血清神经元特异性烯醇化酶（NSE）、恶性肿瘤生长因子（TSGF）7种血清肿瘤标志物的检测。结果：研究组的7种血清肿瘤标志物水平与对照组相比，有统计学意义（P〈0．05）；鳞癌患者的Cyfra21—1阳性率显著高于腺癌患者，且CEA、CA125、CAl5—3阳性率显著低于腺癌患者，有统计学意义（P〈0．05）；非小细胞肺癌（NSCLC）患者CA19—9、CA125、CA15—3的阳性率显著高于小细胞肺癌（SCLC）患者，有统计学意义（P〈0．05）；NSCLC患者的NSE阳性率显著低于SCLC患者，有统计学意义（P〈0．05）；7种血清肿瘤标志物联合检测的灵敏度为91．07％、特异度为86．54％、准确度为88．89％，均显著高于任意单项检测，有统计学意义（P〈0．05）。结论：对肺癌患者进行多种血清肿瘤标志物联合检测，能有效提高肺癌诊断的灵敏度、特异度及准确度，有利于为临床肺癌的鉴别与诊断提供更多的依据，从而减少临床误诊、漏诊等情况的发生。

OBJECTIVE ： To analysis value and role of serum tumor markers in the patients. METHODS ： 216 patients with lung cancer were divided into treatment group （n = 104） and control group （n = 104）. CEA, CA199, CA125, CA153, Cyfra21 - 1, NSE and TSGF7 kinds of serum tumor markers were detected by chemiluminescent in two groups. RESULTS： There was statistically significant difference in 7 kinds of serum tumor markers between the two groups （P 〈 0. 05 ）. Cyfra21 - 1 positive rate was significantly higher than that and CEA, CA125 in the patients with squamous cell carcinoma adenoearcinoma and CA15 -3 positive rates were signficantly lower than that in the patients with adenocarcinoma. There was statistically significant differance （ P 〈 0. 05 ）. The positive rate of CA199, CA125 and CA153 in the patients with NSCLC was significantly higher than those in the patients with SCLC. There was statistically significant differance （ P 〈 0. 05 ）. NSE - positive rate in patients with NSCLC was significantly lower than that in the patients with SCLC. There was statistically significant differance （ P 〈 0. 05 ）. The detective sensitivity of 7 kinds of serum tumor markers was 91.07% , specificity 86. 54% , accuracy 88.89% , which was significantly higher than those in any individual tesing. There was statistical significance difference （ P 〈 0. 05 ）. CONCLUSION ： The serum tumor markers detected by variety of testing ways can effectively increase the sensitivity, specificity and accuracy of diagnosis of lung cancer, which can help to provide more evidence to clinical identification and diagnosis of lung cancer.