复方龙血竭胶囊辅助西药治疗急性心肌梗死患者40例临床观察

Clinical Observation on 40 cases of Acute Myocardial Infarction treated with Western Medical Treatment and Compound Longxuejie Capsules

目的观察复方龙血竭胶囊辅助西医常规治疗方案治疗急性心肌梗死的临床疗效。方法将80例急性心肌梗死患者随机分成观察组和对照组各40例。观察组患者在西医常规治疗基础上给予复方龙血竭胶囊口服,每次1.2 g,每日3次;对照组在西医常规治疗基础上口服螺内酯片,每次30 mg,每日1次。两组均治疗30天后观察临床疗效,治疗前后检测血钾水平、左心室末径以及丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、血肌酐(SCr)、尿素氮(BUN)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白(TNT)水平。结果观察组临床总有效率为100%,明显高于对照组的80%(P<0.05)。两组患者治疗前后比较血钾水平均无明显变化(P>0.05)。观察组治疗后左心室末径低于本组治疗前及对照组治疗后(P<0.05)。两组治疗后ALT、AST、SCr、BUN、CK、CK-MB、TNT水平均较治疗前明显改善(P<0.05);观察组治疗后ALT、AST、SCr、CK、CK-MB、TNT水平低于对照组(P<0.05),BUN高于对照组(P<0.05)。结论复方龙血竭胶囊辅助西医常规治疗方案治疗急性心肌梗死患者能够显著提高临床疗效,改善患者生化指标。

Objective To observe the clinical efficacy of Compound Longxuejie Capsules combined with western medical routine treatment on 40 patients with acute myocardial infarction（ AMI）. Methods Eighty AMI patients were randomly divided into observation group and control group,with 40 in each. For 30 days,on the basis of routine western medical treatment,the observation group was given Compound Longxuejie Capsules,1. 2 g each time,3 times per day,while the control group was given spironolactone instead,30 mg per time,1 time per day. Left ventricular end diastolic（ LVED）,serum levels of potassium,alanine aminotransferase（ ALT）,aspartate aminotransferase（ AST）,serum creatinine（ SCr）,blood urea nitrogen（ BUN）,creatine kinase（ CK）,creatine kinase isoenzyme（ CK-MB） and cardiac troponin（ TNT） were detected before and after treatments. Results The total clinical efficiency in the observation group was 100%,which was higher than that in the control group（ 80%,P〈0. 05）. There was no significant difference in serum levels of potassium in both groups between before and after treatment（ P 〉0. 05）. After treatment,LVED in the observation group was lower than that before treatment in the same group and after treatment in the control group（ P〈0. 05）. The levels of ALT,AST,SCr,BUN,CK,CK-MB,and TNT were significantly improved after treatments in both groups（ P〈0. 05）,but the levels of ALT,AST,SCr,CK,CK-MB and TNT in the observation group were lower than those in the control group（ P〈0. 05）,and the BUN level in the observation group was higher than that in the control group（ P〈0. 05）. Conclusion Applying western medical treatment combined with Compound Longxuejie Capsules on AMI patients could improve clinical efficacy notably and better patient＇s biochemical indexes.