三种化疗方案治疗晚期上皮性卵巢癌的疗效比较

Comparative Study on three Chemotherapeutic Regimens for the Treatment of Advanced Epithelial Ovarian Cancer

目的 :确定治疗晚期上皮性卵巢癌的最佳一线化疗方案。方法 :回顾性分析 1992年 1月至 1999年 1月收治的晚期上皮性卵巢癌患者的治疗结果。对采用 PAM加 HMM(米法兰加六甲咪胺 )、PAC方案或 PC方案及 TP方案治疗的 92例患者的化疗疗效进行了比较。结果 :1TP方案的总有效率显著高于 PAM加 HMM(P<0 .0 5 ) ;2 TP方案的完全缓解率显著高于 PAM加 HMM和 PAC或 PC(P<0 .0 5 ) ;3TP方案的 2年无瘤存活率显著高于 PAM加 HMM和 PAC或 PC(P<0 .0 5 )。结论 :对晚期上皮性卵巢癌患者 ,TP方案效果优于 PAM加 HMM方案及 PAC和 PC方案 。

Objective:To investigate the best first-line chemotherapy regimen for the treatment of advanced epithelial ovarian cancer.Methods: The efficacy of three chemotherapy regimens for treatment of the patients with advanced epithelial ovarian cancer in our hospital during 1992～1999 was retrospectively analyzed.The results were compared with the supplement of PAM+HMM(Melphalan+Hexamethylme),PAC or PC,TP combined chemotherapy after cytoreductive surgery.Results: ①The overall response rate of TP is significantly higher than that of PAM+HMM(P<0.05);②The complete response rate of TP is significantly higher than those of PAM+HMM and PAC or PC(P<0.05,respectively);③The 2-year survival rate free of tumor of TP is obviously higher than those of PAM+HMM and PAC or PC(P<0.05,respectively).Conclusion: We conclude that the TP regimen is better than PAM+HMM and PAC or PC,it is currently the preferred first-line regimen for treatment of advanced epithelial ovarian cancer.