达立通颗粒联合奥美拉唑治疗胃食管反流的临床观察

Clinical Observation of Dalitong Granules Combined with Omeprazole in the Treatment of Gastroesophageal Reflux

目的:观察达立通颗粒联合奥美拉唑治疗胃食管反流的临床疗效和安全性。方法:将104例胃食管反流患者随机均分为对照组和观察组。对照组患者给予多潘立酮片1片,饭前30 min口服,tid+奥美拉唑肠溶胶囊1粒,口服,bid;观察组患者在对照组治疗的基础上给予达立通颗粒1袋,口服,tid。两组患者疗程均为30 d。观察两组患者临床疗效,治疗前后临床症状评分、食管黏膜病变分级情况及不良反应。结果:观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组患者临床症状评分、食管黏膜病变分级情况比较,差异均无统计学意义(P>0.05)。治疗后两组患者临床症状评分均显著低于同组治疗前,且观察组低于对照组;食管黏膜病变N、M级例数均显著多于同组治疗前,且观察组多于对照组;A、B、C、D级例数均显著少于同组治疗前,且观察组A、B级例数少于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:达立通颗粒联合奥美拉唑治疗胃食管反流较奥美拉唑疗效更显著,且安全性较好。

OBJECTIVE： To observe the clinical efficacy and safety of Dalitong granule combined with omeprazole in the treatment of gastroesophageal reflux. METHODS： 104 patients with gastroesophageal reflux were randomly divided into control group and observation group. Control group was treated with Domperidone tablet orally, one tablet, 30 rain before meal, tid; and Omeprazole enteric-coated capsule orally, one capsule, bid. Observation group was additionally treated with Dalitong granules orally, one bag, tid, on the basis of control group. Treatment course of 2 groups lasted for 30 d. Clinical efficacies of 2 groups were observed, and clinical symptom score, gastric mucosal lesion grading and the occurrence of ADR were observed before and after treatment. RESULTS： The total effective rate of observation group was significantly higher than that of control group; there was sta- tistical significance （P〈0.05）. There was no statistical significance in clinical symptom score and case number of gastric mucosal lesion grading between 2 groups before treatment （P〉0.05）. Clinical symptom score of 2 groups after treatment were all significant- ly lower than before, and that of observation group was lower than that of control group; case number of N and M grade esopha- geal mucosal lesion after treatment were significantly more than before, and that of observation group was more than that of control group; case number of A, B, C and D grade after treatment were significantly less than before, and that of A and B grade in observation group were less than in control group; there was statistical significance （P〈0.05）. The incidence of ADR in observation group was significantly lower than in control group; there was statistical significance （P〈0.05）. CONCLUSIONS： Dalitong granules combined with omeprazole is more effective and safer than omeprazole in the treatment of gastroesophageal reflux.