摘要
目的:观察达立通颗粒联合奥美拉唑治疗胃食管反流的临床疗效和安全性。方法:将104例胃食管反流患者随机均分为对照组和观察组。对照组患者给予多潘立酮片1片,饭前30 min口服,tid+奥美拉唑肠溶胶囊1粒,口服,bid;观察组患者在对照组治疗的基础上给予达立通颗粒1袋,口服,tid。两组患者疗程均为30 d。观察两组患者临床疗效,治疗前后临床症状评分、食管黏膜病变分级情况及不良反应。结果:观察组患者总有效率显著高于对照组,两组比较差异有统计学意义(P<0.05)。治疗前两组患者临床症状评分、食管黏膜病变分级情况比较,差异均无统计学意义(P>0.05)。治疗后两组患者临床症状评分均显著低于同组治疗前,且观察组低于对照组;食管黏膜病变N、M级例数均显著多于同组治疗前,且观察组多于对照组;A、B、C、D级例数均显著少于同组治疗前,且观察组A、B级例数少于对照组,差异均有统计学意义(P<0.05)。观察组患者不良反应发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:达立通颗粒联合奥美拉唑治疗胃食管反流较奥美拉唑疗效更显著,且安全性较好。
OBJECTIVE: To observe the clinical efficacy and safety of Dalitong granule combined with omeprazole in the treatment of gastroesophageal reflux. METHODS: 104 patients with gastroesophageal reflux were randomly divided into control group and observation group. Control group was treated with Domperidone tablet orally, one tablet, 30 rain before meal, tid; and Omeprazole enteric-coated capsule orally, one capsule, bid. Observation group was additionally treated with Dalitong granules orally, one bag, tid, on the basis of control group. Treatment course of 2 groups lasted for 30 d. Clinical efficacies of 2 groups were observed, and clinical symptom score, gastric mucosal lesion grading and the occurrence of ADR were observed before and after treatment. RESULTS: The total effective rate of observation group was significantly higher than that of control group; there was sta- tistical significance (P〈0.05). There was no statistical significance in clinical symptom score and case number of gastric mucosal lesion grading between 2 groups before treatment (P〉0.05). Clinical symptom score of 2 groups after treatment were all significant- ly lower than before, and that of observation group was lower than that of control group; case number of N and M grade esopha- geal mucosal lesion after treatment were significantly more than before, and that of observation group was more than that of control group; case number of A, B, C and D grade after treatment were significantly less than before, and that of A and B grade in observation group were less than in control group; there was statistical significance (P〈0.05). The incidence of ADR in observation group was significantly lower than in control group; there was statistical significance (P〈0.05). CONCLUSIONS: Dalitong granules combined with omeprazole is more effective and safer than omeprazole in the treatment of gastroesophageal reflux.
出处
《中国药房》
CAS
北大核心
2015年第3期308-310,共3页
China Pharmacy