阿立哌唑致不良反应67例文献分析

Literature Analysis of 67 Cases of ADR Induced by Aripiprazole

目的：探讨阿立哌唑致不良反应（ADR）的一般规律和特点,为临床合理用药提供参考。方法：检索2002-2013年我国医药期刊报道的阿立哌唑致ADR病例,并就收集到的67例ADR相关信息进行分类、统计和分析。结果：阿立哌唑致ADR与性别无关,多发生于20~39岁;用药6个月内ADR发生率较高;以神经系统及心血管系统损害较为多见。66例患者均恢复正常,1例患者因Ⅲ度房室传导阻滞未恢复正常。结论：尽管阿立哌唑安全性和耐受性均较好,但临床仍需高度重视用药监测,以减少ADR的发生,确保用药安全。

OBJECTIVE： To explore the general regularity and characteristics of ADR induced by aripiprazole, and to provide reference for clinical rational drug use. METHODS： ADR induced by aripiprazole reported by domestic journals during 2002-2013 were retrieved, and 67 included ADR cases were classified and analyzed statistically. RESULTS： Aripiprazole-induced ADR had nothing to do with gender, and often occurred in 20-39 years old group; the incidence of ADR was high within 6 months after medication; nervous system and vascular system damage were the most common. 66 patients had recovered; one patient hadn＇t recovered due to Ⅲ degree atrioventricular heart-block. CONCLUSIONS： Although aripiprazole is safe and well tolerable, great importance should be attached to drug use monitoring to reduce the occurrence of ADR and the safety of drug use.