Tbx3基因在肿瘤进展中的机制

Mechanism of Tbx3 gene in tumor progression

Tbx3（T-box3）基因作为T-box家族的成员之一,广泛存在于人体的多种组织和器官中,参与了胚胎时期乳腺、四肢、心脏、眼、肺、胰腺的发育调控,并且在维持胚胎干细胞的发育中发挥了重要作用.最新研究表明,Tbx3可以作为转录因子通过上皮间质转化、肿瘤干细胞和甲基化等多种途径参与肿瘤的发生和发展.更好地了解Tbx3将为肿瘤的基因诊断和靶向治疗提供新的思路.

As a member of T-box family,Tbx3 （T-box3） is widely expressed in multiple organs and involves in the development of breast,limb,heart,eye,lung and pancreas during embryonic development stage.Moreover,Tbx3 plays an important role in maintaining the embryonic stem cells.Recent studies show that Tbx3 can work as a transcription factor to participate in the initiation and progression of tumor by epithelialmesenchymal transition,induction tumor stemness and methylation.A better understanding of Tbx3 will provide new insights into genetic diagnosis and targeted treatment of tumor.