脂肪因子与结直肠癌

Adipokines and colorectal cancer

脂联素、瘦素、网膜素、内脂素均为脂肪组织细胞分泌的脂肪因子,与肥胖、胰岛素抵抗密切相关.研究发现上述脂肪因子也与结直肠癌的发生发展密切相关,有望成为结直肠癌临床诊断以及预后判断的生物学标志物.目前关于脂肪因子如何诱发结直肠癌的机制尚不清楚,仍需开展深入的研究.

Adipocytokines included adiponectin,leptin,omentin and visfatin are secreted by adipocytes and closely associated with obesity and insulin resistance.Many studies find that these adipocytokines are correlated with the occurrence and development of colorectal cancer,and may be promising biomarkers with respect to clinical diagnosis and prognosis of colorectal cancer.At present,the occurrence mechanisms of colorectal cancer induced by adipocytokines are unclear and needed to be extensively explored.