血清IgA、IgM和IgG水平在肝病诊断中的意义

Value of Serum Lelvels of IgA, IgM&IgG in Diagnosis of Hepatic Diseases

目的:分析研究血清免疫球蛋白检测在肝病诊断中的意义。方法:取不同类型的病例包括急性肝炎、慢性肝炎、肝硬化患者的病例156例,健康对照组50例,分别检测其血清中Ig A、Ig M和Ig G含量,并比较不同组别的差异以及病情的发展程度。结果:62例急性肝炎患者的Ig G、Ig M与正常对照组比较有显著差异(P<0.05),而Ig A与正常对照组比较无明显差异(P>O.05);50例慢性肝炎患者的Ig M与正常对照组比较差异无显著性(P>0.05),其它差异均有高度显著性(P<0.0O1);肝炎肝硬化Ig G、Ig A和Ig M均明显高于正常对照组(P<0.01)。结论:检测血Ig A、Ig M和Ig G的结果可以作为观察慢性肝炎和肝硬化患者病情的活动性的有力证据。

Objective： To investigate the significance of detecting immunoglobulin in serum in diagnosis of hepatic diseases.Methods： Select 165 cases of different hepatic disesases ,including acute hepatitis ,chronic hep-atitis and cirrhosis, and the control group is made up of 50 cases of healthy people. Detect the content of IgA, IgM and IgG in serum respectively and compare the differences and the development of patient condition in each group. Results：Compared with normal control group, the content of IgG and IgM of 62 cases of acute hepatitis pa-tients is greatly different （P〈0.05） ,but there is no obvious difference of IgA （P〈0.001）. Compared with normal con-trol group, there is no obvious difference of IgM in the group of 50 cases of acute hepatitis （P〈0.05）,while other dif-ferences are remarkable （P〈0.001）. The content of IgA, IgM and IgG of cirrhosis are obviously higher than that of normal control group （P〈0.001）. Conclusion： The detection results of IgA, IgM and IgG in serum can be effective evidences to observe the development of patient condition of chronic hepatitis and cirrhosis.