格列美脲联合胰岛素治疗肥胖型2型糖尿病的作用分析

The Clinical Effect of Glimepiride and Insulin in the Treatment of Obese Type 2 Diabetes Mellitus

目的探讨格列美脲联合胰岛素治疗肥胖型2型糖尿病的临床疗效。方法选取126例肥胖型2型糖尿病患者随机分为对照组(n=63)和治疗组(n=63),对照组在控制饮食和合理运动的基础上,给予餐时胰岛素联合二甲双胍缓释片,治疗组在对照组基础上给予格列美脲,治疗12周后比较两组临床疗效。结果治疗后两组FBG、2 h PG、Hb Al C均显著下降(P<0.05),且治疗组下降更明显(P<0.05);治疗组治疗后BMI较治疗前显著下降(P<0.05),而对照组BMI治疗前后比较差异无统计学意义(P>0.05)。治疗后两组TC、TG及LDL-C显著下降(P<0.05),且治疗组下降更明显(P<0.05)。结论格列美脲联合胰岛素治疗肥胖型2型糖尿病可显著改善患者的血糖和血脂水平,对肥胖型2型糖尿病的治疗具有重要临床价值。

OBJECTIVE To explore the clinical effect of glimepiride ang insulin in the treatment of obese type 2 diabetes mellitus.METHODS 126 cases of obese type 2 diabetes mellitus were divided into control group（n=63） and treatment group（n=63）. The pa-tients of control group were given mealtime insulin and metformin hydrochloride sustained-release tablets on the basis of balance dietand fitting exercise. The patients of treatment group were given glimepiride on the basis of control group. After 12 weeks, the clinicaleffect of two groups were compared. RESULTS After treatment, the FBG,2 h PG and Hb Al C of two groups had dropped significant-ly（P〈0.05）, and the change was significantly greater in the treatment group（P〈0.05）. After treatment, the BMI of treatment group haddropped significantly（P〈0.05）, but no apparent effect was observed in the control group（P〈0.05）. CONCLUSION The glimepirideand insulin in the treatment of obese type 2 diabetes mellitus can improve levels of blood sugar and cholesterol, and it had importantclinical significance.