Narcotrend监测下右美托咪定对冠心病患者麻醉诱导期血流动力学的影响

Effect of dexmedetomidine on hemodynamic indexes of patients with coronary heart disease under Narcotrend monitoring

目的:探讨在Narcotrend监测下针对冠心病患者采用右美托咪定对麻醉诱导期的血流动力学的影响。方法:选取外科手术并行全身麻醉的冠心病患者54例,随机将其分为对照组与观察组,各27例,对照组麻醉诱导前仅给予生理盐水,观察组用等量右美托咪定,比较两组麻醉诱导期的血流动力学指标。结果:观察组病例丙泊酚应用剂量、麻醉诱导时间以及意识消失时间与对照组比较均存在明显差异(P<0.05);对照组病例在T3时间后的监测指标异常状况明显高于对照组,其平均动脉压变化幅度较大,同时两组病例靶控输注浓度以及T2麻醉趋势指数比较差异具有统计学意义(P<0.05)。结论:针对冠心病全麻患者在Narcotrend监测下于麻醉诱导前给予右美托咪定可显著降低麻醉诱导期间血流动力学的异常变化。

Objective： To explore effect of dexmedetomidine on hemodynamic indexes of patients with coronary heart disease under Narcotrend monitoring. Methods： A total of 54 coronary heart disease cases with surgery under general anesthesia were selected and randomly divided into control group and observation group by half. Patients in control group were given with only saline before anesthesia, while patients in observation group with dexmedetomidine. Hemodynamic indexes were compared. Results： There were significant differences in dosage of propotol, anesthesia induction time and time of unconsciousness between two groups （P〈0.05）. These indexes after T3 showed more significant changes （P〈0.05）, amplitude of variation in mean arterial pressure was more significant in control group （P〈0.05）. There were signifieant differences in target controlled infusion concentration and T2 anesthesia tendency indexes between two groups （P〈0.05）. Conclusions： Application of dexme- detomidine before anesthesia induction can significantly reduce abnormal changes in hemodynamic indexes for coronary heart disease patients.