四逆散治疗肝胃不和型慢性胃炎的临床研究

Clinical Study of Sini Powder in Treatment of Chronic Gastritis of Liver-Stomach Disharmony Type

目的:探讨四逆散在肝胃不和型慢性胃炎中的临床效果。方法:以2012年1月—2013年11月本院74例肝胃不和型慢性胃炎患者为研究对象,将其随机分为两组,观察组(36例)使用四逆散治疗,对照组(38例)使用多潘立酮片治疗,观察两组的综合疗效、中医证候疗效、Hp清除率和复发率,SDS和SAS评价两组的心理状态。结果:观察组总有效率94.44%,对照组总有效率76.32%,组间比较差异具统计学意义(P<0.05);观察组治疗后中医证候积分(4.3±2.9)分,对照组为(7.6±5.4)分,两组均明显好于治疗前,观察组明显好于对照组,上述差异比较具有统计学意义(P<0.05);观察组的幽门螺杆菌清除率94.44%,对照组68.42%,组间比较差异显著(P<0.05);随访半年观察组复发率5.56%,对照组复发率31.58%,组间比较差异显著(P<0.05);观察组治疗后SDS和SAS评分为(32.3±6.2)分和(41.8±5.8)分,两项指标均显著优于对照组(P<0.05)。结论:四逆散治疗肝胃不和型慢性胃炎近远期疗效显著,降低了复发率,缓解患者不良心理,值得临床推广应用。

Objective： To investigate the clinical effect of Sini Powder in the liver-stomach disharmony syndrome in chronic gastritis. Methods： From January 2012-November 2013 in our hospital,74 cases of chronic gastritis of liver-stomach disharmony type were as the object of study and randomly divided into two groups. The observation group（ 36 cases） used Sini Powder and the control group（ 38 cases） used Domperidone Tablets. We observed the comprehensive curative effect,two groups＇ TCM syndrome before treatment,Hp removal rate and recurrence rate,SDS and SAS evaluation of the psychological state of two groups. Results： The observation group＇s total effectiveness was 94. 44% and the control group＇s was 76. 32%. there were statistically significant differences between two groups（ P〈0. 05）. After treatment,the observation group＇s TCM syndrome score was（ 4. 3 ± 2. 9）and that of the control group was（ 7. 6 ± 5. 4）,which were both significantly better than those before treatment in two groups.The observation group was significantly better than the control group and the difference was statistically significant（ P〈0. 05）.The observation group＇s Helicobacter pylori clearance rate was 94. 44% and it was 68. 42% in the control group and the difference between two groups was significant（ P〈0. 05）. After followed up for half a year,the observation group＇s recurrence rate was5. 56% and the control group＇s was 31. 58% and the difference between two groups was significant（ P〈0. 05）. After treatment,the observation group＇s SDS and SAS scores were（ 32. 3 ± 6. 2） and（ 41. 8 ± 5. 8）,which were significantly better than those of the control group（ P〈0. 05）. Conclusion： Sini Powder in treatment of liver-stomach disharmony type of chronic gastritis has short and long-term curative effect and can reduce the recurrence rate and alleviate the adverse mental patients,worthy of clinical application.