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利妥昔单抗联合CHOP方案治疗非霍奇金淋巴瘤的疗效观察 被引量:9

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摘要 目的探讨利妥昔单抗联合CHOP方案治疗非霍奇金淋巴瘤(NHL)的临床疗效。方法收集2008年1月至2012年1月,我院收治的NHL患者58例,随机分为观察组与对照组,观察组予以利妥昔单抗联合CHOP方案治疗,对照组单独应用CHOP方案治疗,比较两组的临床疗效。结果观察组的治疗总有效率为89.7%,显著高于对照组的72.4%(P<0.05);观察组不良反应与对照组无明显差异(P>0.05)。结论妥昔单抗联合CHOP方案治疗非霍奇金淋巴瘤疗效显著,不增加不良反应,值得推广应用。
作者 王莹
出处 《中国医药指南》 2015年第1期73-74,共2页 Guide of China Medicine
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  • 1夏忠军,王风华,黄慧强,骆卉妍,李宇红,林桐榆,姜文奇,管忠震.含美罗华方案治疗B细胞性惰性淋巴瘤34例报告[J].癌症,2006,25(4):490-494. 被引量:9
  • 2Yun J,Kim SJ,Kim JA,et al.Clinical features and treatment outcomes of non-Hodgkin′s lymphomas involving rare extranodal sites:a single-center experience[J].Acta Haematol,2010,123(1):48.
  • 3Zwick C,Gleissner B,Pfreundschuh M.Aspects of chemotherapy schedules in young and elderly patients with aggressive lymphoma[J].Clin Lymphoma Myeloma,2007,8(Suppl 2):S43.
  • 4Wilson WH,Gutierrez M,O′Connor P,et al.The role of rituximab and chemotherapy in aggressive B-cell lymphoma:a preliminary report of dose-adjusted EPOCH-R[J].Semin Oncol,2002,29(1 Suppl 2):41.
  • 5Kewalramani T,Zelenetz AD,Nimer SD,et al.Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma[J].Blood,2004,103(10):3684.
  • 6Samuel AJ,Kenneth AF.The expanding role of rituximab and radioimmunotherapy in the treatment of B-cell lymphomas[J].Expert Opin,2007,7(11):1749-1762.
  • 7Coiffier B.Rituximab therapy in malignant lymphoma[J].Oncogene,2007,26:3603-3613.
  • 8Martin J.Glennie mechanisms of killing by anti-CD20 monclonal antibodies[J].Molecular Immunology,2007,44:3823-3837.
  • 9Mounier N,Briere J,Gisselbrecht C.Rituximab plus CHOP (R-CHOP) overcomes Bcl2-associated resistance to chemotherapy in elderly patients with diffuse large B-cell lymphoma (DLBCL)[J].Blood,2003,101(11):4279-4284.
  • 10Hainsworth JD,Litchy S,Burris HA,et al.3rd rituximab as first line and maintenance therapy for patients with indolent non2Hodgkin's lymphoma[J].J Clin Oncol,2002,20(20):4261-4267.

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  • 1林东军,李旭东,林曲,夏忠军,黄仁魏,吴祥元,方志刚.利妥昔单抗联合CHOP方案治疗非霍奇金淋巴瘤疗效观察[J].新医学,2005,36(9):522-524. 被引量:7
  • 2温继育,谢忠,谢杰荣.利妥昔单抗联合DHAP方案治疗复发性非霍奇金淋巴瘤的临床疗效[J].肿瘤研究与临床,2006,18(7):462-463. 被引量:2
  • 3王亚兰,王丽霞,银素芳.CTOP与CHOP方案治疗老年非霍奇金淋巴瘤的临床对照研究[J].中国肿瘤临床与康复,2007,14(5):453-456. 被引量:5
  • 4Cheson BD, Homing SJ, Coiffier B,et al.Report of an in- ternational workshop to standardize response criteria for non-Hodgkin's lymphomas [ J].J Clin Oncol, 1999, 17 (4) : 1244-1253.
  • 5Pasqualucci L,Dalla-Favera R.The Genetic Landscape of Diffuse Large B-Cell Lymphoma [ J ]. Semin Hematol, 2015,52(2) :67-76.
  • 6Ha H, Keam B, Kim TM, et al. Reduced dose intensities of doxorubicin in elderly patients with DLBCL in rituximab era [ J ]. Cancer Res Treat, 2015, 10 ( 41 ) : 339-342.
  • 7Tsai PC, Hernandez-Ilizaliturri FJ, Bangia N, et al. Regu- lation of CD20 in rituximab-resistant cell lines and b-cell non-hodgkin tymphoma [ J ]. Clin Cancer Res, 2012, 18 (4) : 1039-1050.
  • 8Ulrich W, Riccardo AA. Diffuse large B-cell Non- Hodgkin' s lymphoma (DLBCL-NHL) [ M ]. London : Springer, 2015 : 185 -202.
  • 9Molina A.A deeade of rituximab: improving survival out- comes in non-Hodgkin' s lymphoma[ J ].Annu Rev M ed, 2008,59(12) :237-250.
  • 10Habermann TM, Weller EA, Morrison VA, et al.Rituximab- CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma[J].J Clin Oneol,2006,24(19) : 103.

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