药物入壶后输出液药物浓度峰值的影响因素

The influencing factors of peak concentration of drug administrated by drip chamber

目的:探索药物入壶后输出液药物浓度峰值变化规律并分析其影响因素,为临床规范应用这一给药方式提供理论依据。方法:用紫外可见光光度仪连续监测龙胆紫饱和溶液入壶后输出液体的吸光度,将测得的吸光度转换成药物浓度,获得输出液药物浓度峰值。分别设定输液速度为90,180,360,720 ml·h-1;输液器滴壶内液体量分别设定为2,3,4 ml;入壶溶液分别为1,2 ml。对实验结果进行统计学分析。结果:输液速度(x1)、滴壶内液体量(x2)、入壶药量(x3)对输出液药物浓度峰值(y)均有影响,差异具有统计学意义(P<0.05)。对于3个影响因素的多元线性回归分析得到^y=7.283+0.003 x1-1.904x2+8.820 x3(R2=0.947,F=547.080),三者影响由大到小依次为:入壶药量、壶内液量、输液速度。入壶药量越大,输出液药物浓度峰值越高,壶内液量越多输出液药物浓度峰值越低,输液速度越快输出液药物浓度峰值越高。结论:入壶给药时输出液药物浓度受多种因素影响,与静脉注射药物浓度变化规律不同,一些药物不能采用入壶方式代替静脉注射。

OBJECTIVE To study the changing rules of peak concentration of output liquid after drug was administrated by drip chamber.METHODS An ultraviolet-visible spectrophotometer was used to monitor output liquid absorbance after saturated gentian violet solution was added.The absorbance was transformed into drug concentration,and then we could acquire the peak concentration.The infusion rates were respectively set at 90,180,360,720 ml·h-1,the liquid volumes in drip chamber were 2 ml,3 ml and 4 ml,and added volumes of gentian violet solution were 1 ml and 2 ml.The experimental results were statistically analyzed.RESULTS The peak concentration of drug in output liquid was affected by infusion rate（x1）,liquid volume in drip chamber（x2）and the volume of gentian violet solution（x3）,with statistically significant differences（P〈0.05）.We had obtained a multiple linear regression equation^y=7.283＋0.003x1-1.904x2＋8.820x3（r2=0.947,F=547.080）and the three factors were ordered by：x3〉x2〉x1.More drug volume and quicker infusion rate would result in higher peak concentration,while more liquid volume in drip chamber would result in lower peak concentration.CONCLUSION Drug concentration in output solution can be affected by many factors,which is different from the changing laws of drug solution intravenously injected.Therefore,some drugs cannot be administered by drip chamber to replace intravenous injection.