消痔灵肛垫悬吊固化作用的动物实验研究

Animal Experimental Study of Xiaozhiling for Anal Cushion Suspensory Cure

目的:观察消痔灵对家兔直肠黏膜的局部影响,研究消痔灵肛垫悬吊固化作用的机理。方法:10只10月龄普通级新西兰白兔,雌雄各半,将消痔灵原液0.5 mL在直肠3点位一次注入直肠黏膜下,3天后颈椎脱臼处死动物,留取样本,制作病理切片,镜下观察注射部位与未注射部位的局部变化。结果:10份标本在光镜下见注射消痔灵部位有大量肌纤维增生,未见局部组织坏死及炎症反应。结论:消痔灵肛垫悬吊固化作用是通过刺激局部大量肌纤维增生形成的。

Objective： To observe the local effect of Xiaozhiling on rectal mucosa of rabbits, and to explore the mechanism of suspension and curing of Xiaozhiling. Methods： Ten ten-month-old New Zealand white rabbits half male and half female were injected 0.5 mL Xiaozhiling stock solution at three points of rectal mucosa in one time. After three days, the experimental animals were sacrificed by cervical dislocation and the samples were taken to make the pathological section for local changes observation both on injection sites and non-injection sites by microscope. Results： There were massive muscle fibers hyperplasia without local tissue necrosis and inflammationat on the injection sites in all the ten samples. Conclusion： The suspension and curing effect of anal cushion from Xiaozhiling is obtained through stimulating local massive muscle fibers hyperplasia.