高血压病患者不同糖代谢下血清铁蛋白水平与胰岛β细胞功能相关性研究

Correlation of serum ferritin level with islet β cell function in hypertension patients with different glucose metabolism

目的探讨高血压病患者不同糖代谢下血清铁蛋白(SF)水平与胰岛β细胞功能的关系。方法纳入2009年1月至2011年6月内分泌门诊就诊的高血压病患者112例,测量体质指数(BMI)、腰围(WC),测定血清指标:空腹血糖(FPG)、胆固醇(CHO)、甘油三酯(TG)、高低密度脂蛋白胆固醇(HDL-C、LDL-C)、尿酸(UA)、空腹胰岛素(FTI)及SF,据75g口服葡萄糖耐量实验分为糖代谢正常(NGT)组、糖调节受损(IGR)组和新发糖尿病组。结果(1)新诊断2型糖尿病(糖尿病组)36例(32.1%),IGR 46例(41.1%),NGT 30例(26.8%)。(2)3组间BMI、WC、CHO、LDL-C、HDL-C比较差异无统计学意义(P均>0.05);糖尿病组的FPG、FTI、TG、SF、HOMA-IR明显高于IGR组和NGT组,UA高于NGT组而HOMA-β低于NGT组,IGR组的FPG、TG、SF、HOMA-IR明显高于NGT组,HOMA-β低于NGT组,差异均有统计学意义(P均<0.05)。(3)校正年龄和性别后的偏相关分析显示,SF与FPG(r=0.466,P<0.01)、FTI(r=0.413,P<0.01)、HOMA-IR(r=0.443,P<0.01)呈正相关。结论高血压病患者出现糖代谢异常时,SF水平明显增高,与胰岛素抵抗相关。

Objective To explore the relationship between serum ferritin（SF） level and the islet β cell function in hypertension patients with different glucose metabolism.Methods A total of 112 hypertension patients presented in the department of endocrinology between January 2009 and June 2011 were included in this study.The body mass index（BMI）and waist circuit（WC） were measured;fasting blood-glucose（FPG）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,uric acid（UA）,fasting insulin（FINS） and SF were detected;homeostasis model assessment-insulin resistance index（HOMA-IR） and HOMA β cell function index（HOMA-β） were calculated.According to 75 g glucose tolerance test,the patients were divided into three groups：normal glucose tolerance（NGT） group（30 cases）,impaired glucose regulation（IGR） group（46 cases） and newly diagnostic diabetes mellitus（DM） group（36 cases）.Results There were no statistical differences in the levels of BMI,WC,CHO,LDL-C and HDL-C in three groups（all P 〉 0.05）.The levels of FPG,FINS,TG,SF,HOMA-IR in DM group were all significantly higher than those in IGR group and NGT group（all P 〈 0.05）,and the level of UA in DM group was significantly higher than that in NGT group,while HOMA-β were significantly lower than that in NGT group（all P 〈 0.05）.Compared with NGT group,the levels of FPG,TG,SF and HOMA-IR increased significantly（all P 〈 0.05）,and HOMA-βdecreased significantly（all P 〈 0.05） in IGR group.After the adjustment of age and gender,partial correlation analysis showed that SF was positively correlated with FPG（r = 0.466,P ﹤ 0.01）,FINS（r = 0.413,P ﹤ 0.01） and HOMA-IR（r = 0.443,P﹤ 0.01）,respectively.Conclusion When glucose metabolism abnormality occurs in patients with hypertension,serum SF level can obviously increase,and it is associated with insulin resistance.