摘要
目的探讨快速鉴别药品中降压物质的可行性。方法应用偶氮试验法对药品中的组胺和组胺类物质进行快速显色鉴别,结果与中国药典2010年版的"降压物质检查法"进行验证比较。结果组胺对照品呈现明显的阳性反应,其检测灵敏度为0.125μg,2种方法的检查结果一致。结论所建立的方法为降压物质药害应急事件的处理提供了一种新的思路。
OBJECTIVE To explore the feasibility of rapid identification of depressor substances in drugs. METHODS Method of azo test was applied to identify histamine and histamine like substances in drugs quickly, the result was compared with that of routine method indexed in Chinese Pharmacopeia. RESULTS Control substance of histamine showed positive reaction, the detectability of this method was 0.125 μg, it had good correlation between this new method and routine method. CONCLUSION It provides a new way to deal with the drug emergency induced by depressor substances.
出处
《中国现代应用药学》
CAS
CSCD
2015年第1期59-62,共4页
Chinese Journal of Modern Applied Pharmacy
基金
广东省食品药品监管局药检系统课题(YJ201036)
关键词
组胺
降压物质
鉴别
偶氮试验
histamine
depressor substances
identification
azo test
