痤消饮颗粒治疗痤疮药效学研究

Pharmacodynamical Study on Acne Eliminating Granule in Treatment for Acne

目的：观察祛风清肺、清热解毒中药痤消饮颗粒（CXY，银花、连翘、牛子、荆芥、薄荷等）治疗痤疮的药理效应。方法：观察CXY高、中、低剂量（2、1、1/2倍临床等效剂量，下同）对①痤疮丙酸杆菌所致耳廓痤疮模型大鼠耳廓肿胀度、病变分级和病理的影响；②雄性去势小鼠血清睾酮及精囊腺、前列腺指数；③雌性去势小鼠血清雌二醇（E2）和子宫指数；④棉球肉芽肿大鼠肉芽肿干、湿重；⑤角叉菜胶所致小鼠足跖肿胀度和足跖肿胀率的影响。结果：与模型组相比，CXY三剂量均可显著降低耳廓痤疮大鼠耳廓肿胀度和病变分级（P〈0.01），明显改善大鼠耳廓组织炎性病变；CXY三剂量均可显著减少雄性去势小鼠血清睾酮、精囊腺、前列腺指数（P〈0.05、0.01和0.05），增加雌性去势小鼠血清E2、子宫指数（P〈0.01），减小大鼠棉球肉芽肿湿重和干重（P〈0.01），减少角叉菜胶所致足跖肿胀小鼠足跖肿胀度和肿胀率（P〈0.01）。结论：CXY可能通过增加雌性激素同时抑制雄性激素分泌，并发挥抗炎（增殖性和渗出性）效应，从而缩小痤疮病灶大小、改善痤疮病灶炎性病变分级，有确切的抗痤疮作用，适用于寻常痤疮的临床治疗。

Objective：To observe the pharmacological effect of the herbs that expelling wind and clearing lung, heat clearing and detoxicating that named acne elminating granule （CXY, honeysuckle, forsythia suspensa, fructus arctii, schizonepeta, mint, etc） in treatment for acne. Methods：To ob-serve the influence of high, middle and low CXY dose （2, 1 and 1/2 times clinical equivalent dose, the same below） on①the effect on auricle swell-ing degree, pathological grading and pathology of auricle acne on rat models that caused by propionibacterium acnes;②the serum testosterone and seminal vesicle, prostate indexes of castrated male rats;③the serum estradiol （E2） and uterus index of castrated female rats;④the dry and wet weight of granuloma in tampon granuloma rats; ⑤the swelling degree and rate of rats with paw swelling that caused by carrageenin. Results： Compared with model group, the 3 doses of CXY could all significantly reduce the auricle swelling degree and pathological grading （P〈0.01）, significantly im-prove the inflammatory lesion of rats＆#39; auricle tissue;could all significantly decrease the serum testosterone, seminal vesicle and prostate indexes of castrated male rats （P〈0.05, 0.01 and 0.05）, increase the serum E2 and uterus index of castrated female rats （P〈0.01）, cut down the wet weight and dry weight of tampon granuloma in rats （P〈0.01）, reduce the swelling degree and swelling rate of rats with paw swelling that caused by carrageenin. Conclusion：Increase the female hormone also inhibit the secretion of male hormone, and exert the anti-inflammatory （proliferative and exudative） ef-fect, is the possibly way that CXY narrows the size and improves the inflammatory classification of acne nidus, which has a definite anti acne effect and is suitable for the clinical treatment of acne vulgaris.