摘要
目的：介绍自制低头架（专利号：201220284456．1）的制作，分析其应用价值，为家兔颈椎病的造模提供参考。方法：将30只日本大耳白兔随机分为模型1组、模型2组和对照组，采用自制低头架对模型1、2组进行造模：连续造模2月后，通过观察兔子颈肌硬度变化、超微结构及组织酶学对造模情况进行分析。结果：对照组肌纤维排列规则，粗细均匀，模型1、2组可见多灶性纤维组织增生，灶性肌细胞变形、坏死并伴炎性细胞浸润等：α-SMA在对照组中未见明显表达，模型1、2组中α-SMA染色呈强阳性，比较有显著性差异（P〈0．01）。结论：通过自制低头架能成功建立家兔颈型颈椎病急性期的模型。
Objective： To introduce the fabrication of homemade bow frame and analyze its application value, to provide some references for the molding of cervical spondylosis rabbit. Methods： 30 Japanese white rabbits were randomly divided into model group 1, model group 2 and control group, and the model groupl and 2 were molded by homemade bow frame; after molded for 2 months, analyzed the molding situation by observing the change of cervical muscle hardness, ultrastructure and histoenzymology of rabbits. Results： Control group were detected with muscle fibers in or- der and thickness uniformity without expression of α-SMA. Model group 1 and 2 were detected with multiple focal fibrous hyperplasia, focal muscle cell deformation and necrosis and inflammatory cell infiltration, and high expression of α-SMA. Differences between control group and model group were significant （P〈0.01）. Conclusion： The rabbit model of acute cervical spondylosis can be successfully made by homemade bow frame.
出处
《按摩与康复医学》
2015年第2期122-124,共3页
Chinese Manipulation and Rehabilitation Medicine
基金
国家自然科学基金青年基金项目,编号:81102662
成都中医药大学科技发展基金,编号:ZRYB201104
关键词
颈椎病
自制低头架
造模
家兔
Α-SMA
cervical spondylosis
homemade bow frame
molding
rabbit
α-SMA
