类风湿性关节炎合并冠心病患者的红细胞沉降率与心肌梗死病史的关系

Relationship Between Erythrocyte Sedimentation Rate and Myocardial Infarction Occurrence in Patients With Rheumatoid Arthritis Combining Coronary Artery Disease

目的：探讨类风湿性关节炎合并冠心病患者的红细胞沉降率与发生心肌梗死的关系。 方法：连续入选类风湿性关节炎合并冠心病患者106例，男性46例，女性60例，其中发生过心肌梗死患者46例（心肌梗死组），未发生过心肌梗死患者60例（非心肌梗死组）。比较两组患者的基线资料。用logistic回归的方法探究类风湿性关节炎合并冠心病患者发生心肌梗死的相关危险因素。 结果：胆固醇水平心肌梗死组明显低于非心肌梗死组（P〈0.05）。炎症活动性指标红细胞沉降率，高敏C反应蛋白及C反应蛋白水平心肌梗死组均明显高于非心肌梗死组（P〈0.05）。两组其它基线资料相比均无统计学差异（P〉0.05）。多元logistic回归模型得出该人群发生心肌梗死的相关危险因素为红细胞沉降率（风险比：1.024；95%可信区间：1.007-1.043；P=0.007）。 结论：类风湿性关节炎合并冠心病患者红细胞沉降率与心肌梗死的发生有独立关联。

Objective： To explore the relationship between erythrocyte sedimentation rate （ESR） and myocardial infarction （MI） occurrence in patients with rheumatoid arthritis （RA） combining coronary artery disease （CAD）. Methods： A total of 106 consecutive patients with RA combining CAD were studied. There were 46 male and 60 female patients and divided into 2 groups：RA with MI group, n=46 and RA without MI group, n=60. The base line condition was compared between 2 groups, and multivariate regression analysis was conducted to explore the risk factors for MI occurrence in relevant patients. Results： Compared with RA without MI group, RA with MI group had the lower level of cholesterol and higher levels of inlfammatory indexes of ESR, high sensitivity C-reactive protein （hs-CRP） and CRP, P〈0.05. The base line condition was similar between 2 group, P〉0.05. Multivariate regression analysis indicated that ESR was the independent risk factor of MI occurrence, OR=1.024, 95%CI 1.024 （1.007-1.043）, P=0.007. Conclusion： ESR was independently related to MI occurrence in patients with RA combining CAD.