血清IgA及总IgE与儿童反复呼吸道感染的相关性研究

Study on the Relationship Between Serum IgA and Total IgE with Repeated Respiratory Infection of Children

目的：探讨血清免疫球蛋白A（ IgA）及总免疫球蛋白E（ IgE）与儿童反复呼吸道感染（ RRTI）的相关性研究。方法选取2013－05～2014－05间我院收治的60例RRTI患儿为观察组，选取同时期行健康体检的78例儿童为对照组。比较两组患儿治疗前后血清IgA及总IgE水平。结果观察组患儿治疗前血清IgA水平显著低于对照组（ P＜0.05）；治疗后观察组患儿血清IgA显著提高，与治疗前比较差异具有统计学意义（ P＜0.05），但仍显著低于对照组（ P＜0.05）。观察组患儿治疗前血清IgE水平显著高于对照组（ P＜0.05）；治疗后观察组患儿血清IgE显著降低，与治疗前比较差异具有统计学意义（ P＜0.05），但仍显著高于对照组（ P＜0.05）。结论检测血清IgA及总IgE水平可为RRTI患儿诊治与预后提供参考，且采用免疫调节药物治疗可能是提高临床疗效的有效办法。

Objective To evaluate the relationship between serum IgA and total IgE with repeated respiratory infection of chil -dren.Methods Selecting 60 children with repeated respiratory infection in the hospital from May , 2013 to May, 2014 as the observation group, and 78 health checkup children as the control group.The level of IgA and total IgE in blood serum were compared between the two groups.Results Before treatment , the serum IgA of observation group were significantly lower than control group （ P〈0.05 ）.After treat-ment, the serum IgA of observation group significantly increased , with statistically significant difference compared with before treatment （P〈0.05 ） , but still significantly lower than the control group （ P〈0.05 ）.After treatment , the serum IgE of observation group significantly decreased , with statistically significant difference compared with before treatment （ P〈0.05 ） , but still significantly higher than the control group （ P〈0.05 ）.Conclusion Detection of serum IgA and total IgE level can provide reference for the diagnosis.The immunomodulatory drugs may be an effective way to improve clinical treatment.