深共融溶剂法合成盐酸吗啉双胍

Synthesis of moroxydine hydrochloride with deep eutectic solvents

在吗啉盐酸盐和双氰胺组成的深共融溶剂体系的条件下,以吗啉、浓盐酸、双氰胺为原料通过缩合反应合成盐酸吗啉双胍。讨论反应温度、时间、反应物摩尔比等因素对盐酸吗啉双胍合成收率的影响,重点考察深共融溶剂体系组分间不同摩尔比对体系熔点的影响,以及研究产物的分离和纯化的方法。研究结果表明:在由吗啉盐酸盐和双氰胺组成的深共融溶剂体系的条件下以吗啉、浓盐酸、双氰胺为原料通过缩合反应合成盐酸吗啉双胍的方法简单,产品易于分离。吗啉盐酸盐/双氰胺(mol)为1.0∶0.8和1.0∶1.8时,深共融溶剂体系熔点为48℃。通过对影响因素的考察,找到了使用该法合成盐酸吗啉双胍的最佳合成条件:缩合反应温度为140℃;最佳反应时间为3h;物料配比(mol)为1∶0.8。

Through condensation reaction of moroxydine chloride and dicyandiamide, Moroxydine Hydrochlo- ride was synthesized under the condition of deep eutectic solvents（DESs）. Factors affecting the yield was studied, such as the reaction temperature, reaction time, molar ratio of reactants. We focused on the influence of different molar ratio on DESs melting point. Isolation and purification of Moroxydine Hydrochloride was also studied. The results showed that our synthesis methods has obvious advantages, and the product is easy to separate. When the molar ratio of （DESs） components wasl.0：0.8 and 1.0：1.8, （DESs） has the lowest melting point, the minimum melting point of （DESs） was 48℃. Based on the investigation to the influencing factors, wa found the best synthesis conditions. The optimum reaction temperature useing this method to synthesize moroxydine hydroehloride was 140℃; reaction time was 3 hours; the material ratio was 1：0.8.