水通道蛋白理论在疾病诊断中的应用

The application of water channel protein theory in disease diagnosis

水通道蛋白(AQPs)广泛分布于细胞,介导水分子的跨膜转运。AQPs与人类正常生理活动及多种疾病的发生发展有着密切的联系。以水通道蛋白理论为基础的诊断医学具有巨大的发展潜力,采用正电子核素标记示踪剂PET成像和MR水分子扩散加权成像采用多b值、高b值能够显示AQPs分布和表达水平。AQPs分子成像技术对于疾病早期诊断和指导个体化治疗均具有重要的价值。

The aquaporins （AQPs） are widely distributed in the cells, mediating the transport of water molecules on different types of cell membrane. They are closely related to human normal physiological activities and disease. With the theory of water channel protein in the disease diagnosis, medicine has huge development potential. PET imaging with positron nuclide labeling tracer and MR water molecules diffusion-weighted with different and high b values can show distribution and the expression level of AQPs. AQP molecular imaging technique is of important value not only for the early disease diagnosis but also for the individualized treatment.