益生菌制剂对溃疡型结肠炎患者血清炎性介质的影响

Effects of probiotic preparation on serum inflammatory mediators of patients with ulcerative colitis

目的探讨益生菌制剂对溃疡性结肠炎(UC)患者血清炎性因子IL-6、TNF-α及CRP水平的影响。方法 60例UC患者仅接受美沙拉嗪或激素治疗作为对照组;另60例UC患者在对照组治疗基础上,联合双歧杆菌、嗜酸乳杆菌、肠球菌三联活菌制剂治疗,作为研究组。治疗后2、4 w,检测两组血清IL-6、TNF-α、CRP水平,并进行对比分析。结果治疗后2 w,两组血清IL-6、TNF-α及CRP水平均较治疗前显著降低(P<0.05);治疗后4 w较治疗前下降更为明显(P<0.01)。治疗后2 w,两组血清IL-6、TNF-α及CRP水平无显著差异(P>0.05);但在治疗后4 w,研究组上述3指标均较对照组显著降低(P<0.05)。结论益生菌制剂联合应用有助于抑制UC患者炎性因子IL-6、TNF-α、CRP的表达,从而控制炎症反应。

Objective To explore the effects of probiotic preparation on serum levels of inflammatory factors IL-6,TNF-α and CRP of patients with ulcerative colitis（ UC）. Methods Total 120 patients with UC were selected and divided randomly into the control group and research group（ n = 60,respectively）. The control group was provided with only mesalazine or hormone therapy,and the research group was provided with Bifidobacterium,Lactobacillus acidophilus,and Enterococcus triple viable capsules based on the treatment of control group. After treatment for two and four weeks,the serum levels of inflammatory factors IL-6,TNF-α and CRP were examined and comparative analysis was made. Results After treatment for two weeks,the serum levels of inflammatory factors IL-6,TNF-α and CRP of patients in both groups decreased significantly（ P〈 0. 05）; after treatment for four weeks,the serum levels of above factors decreased more significantly than those before the treatment（ P〈 0. 01）. After treatment for two weeks,the serum levels of IL-6,TNF-α and CRP had no significant difference between the two groups（ P〉 0. 05）,but treatment for four weeks,the levels of above factors of the research group were significantly lower than those of the control group（ P〈 0. 05）. Conclusion The combined application of probiotic preparation can inhibit the expression level of inflammatory factors IL-6,TNF-α and CRP of patients with UC,so as to control the inflammatory reaction.