抗炎天然产物活性成分研究进展

Progress on anti-inflammatory natural products

炎症是具有血管系统的活体组织对各种损伤因子的刺激所发生的防御反应,在人体许多重大疾病的发生发展过程中起着极其重要的作用。临床上应用的抗炎药物主要有非甾体类抗炎药、甾体类抗炎药和中草药。由于现有的化学合成抗炎药物具有明显的不良反应,近年来人们越来越重视从天然产物中寻找、开发抗炎药物。以往的综述主要侧重于天然药物的抗炎机制,而对于天然药物中抗炎活性成分的总结却少有报道,笔者对近年来报道的具有抗炎作用的天然药物活性成分的研究进行综述,以期对进一步开发高效安全的抗炎药物提供参考。

Inflammation is the defense response of the living tissues possessing vascular system to stimulations of various injury factors ,which plays a vital role in the initiation and progression of many major diseases .Drugs used to treat inflammation in the clinical mainly include nonsteroidal antiinflammatory drugs （NSAIDs） ,steroidal antiinflammatory drugs （SAIDs） and traditional Chinese medicine .As synthetic antiinflammatory drugs used in clinical currently have obvious adverse reactions , more and more attention were paid to seek antiinflammatory drugs from natural medicines .Reviews reported before mainly focus on antiinflammation mechanism of natural medicine ,however ,there are few reports on the summary of antiinflammatory natural products .Active natural products which were reported to possess antiinflammatory effects in recent years were summarized in order to provide information for further study of antiinflammatory drugs research .