老年急性脑梗死与血清Hcy和载脂蛋白a、血尿酸、D-二聚体、超敏C-反应蛋白的关系研究

Correlation between acute cerebral infraction and homocysteine,apolipoproteins a,blood uric acid,D-dimer and high sensitive C-reactive protein in the elderly

目的探讨血清同型半胱氨酸（Hcy）和载脂蛋白a[LP（a）]、血尿酸（UA）、D-二聚体（D2）、超敏C-反应蛋白（hs-CRP）与急性脑梗死的关系。方法以2011年6月至2013年10月期间的住院急性脑梗死患者120例（脑梗死组）、同期职工体检中性别和年龄匹配的健康体检者130例（健康对照组）为调查对象,检测血清Hcy和LP（a）、血UA、D2、hs-CRP与急性脑梗死的关系;依据脑梗死患者NIHSS评分分为〈5分、5~15分、〉15分3个亚组,比较血清Hcy和LP（a）、血UA、D2、hs-CRP水平。结果脑梗死组患者血清Hcy和LP（a）、血UA、D2、hs-CRP水平明显高于健康对照组（P〈0.05）;脑梗死组NIHSS评分5~15分、〉15分,血清Hcy和LP（a）、血UA、D2、hs-CRP水平均明显高于〈5分、5~15分及健康对照组（P〈0.05）,〈5分亚组患者Hcy和LP（a）、血UA、D2、hs-CRP水平高于健康对照组（P〈0.05）。结论血清Hcy和LP（a）、血UA、D2水平、hs-CRP水平随着急性脑梗死患者病情的严重程度进行性升高。

Objective To explore the relationship between acute cerebral infraction and homocysteine（ Hcy）,apolipoproteins a[LP（ a） ],blood uric acid（ UA）,D-dimer（ D2） and high sensitive C-reactive protein（ hs-CRP） in the elderly. Methods The levels of Hcy,LP（ a）,UA,D2 and hs-CRP were detected in 120 elderly patients with acute cerebral infarction（ observation group） and 130 healthy subjects（ control group）. The patients with acute cerebral infarction were redivided into three subgroups acording to the scores of NIHSS： 〈5,5 ~ 15, 〉15. Results As compared with those in control group,the levels of Hcy,LP（ a）,UA,D2 and hs-CRP in observation group were significantly increased（ P〈0. 05）. The levels of Hcy,LP（ a）,UA,D2 and hs-CRP in observation group with NIHSS： 5 ~ 15, 〉15 were significantly higher than those of NIHSS：〈5 and control group（ P〈0. 05）. Conclusion The levels of Hcy,LP（ a）,UA,D2 and hs-CRP are increased with the severity of acute cerebral infarction in the elderly.