胰腺腺泡细胞癌临床病理特征分析并文献复习

Clinicopathologic Characteristics of Pancreatic Acinar Cell Carcinoma: a Literature Review

目的探讨胰腺腺泡细胞癌的临床病理学特点及诊断要点。方法对1例胰腺腺泡细胞癌进行临床资料、病理形态及免疫组化观察,并结合文献对其诊断及鉴别诊断进行探讨。结果镜下穿刺组织中瘤细胞小梁状、微腺样排列;瘤细胞呈圆形或多边形,胞浆丰富,呈嗜酸性颗粒状,部分呈空泡状,核圆形至椭圆形、多位于基底部;间质内见大量嗜酸性粒细胞浸润,胞浆内富含嗜酸性颗粒,细胞核轻度异型。免疫组化染色显示Cg A(-),Ki-67(index约15%)和Syn(-)。结论胰腺腺泡细胞癌比较罕见,提高对其的认识,可避免误诊。

Objective To explore the clinicopathologic characteristics and diagnostic criteria of pancreatic acinar cell carcinoma. Methods Clinical data,pathomorphology and immunohistochemical staining of one patient with pancreatic acinar cell carcinoma were observed,and its diagnosis and differential diagnosis combined with literature were also analyzed. Results Microscopic examination showed that the tumor cells were trabecular and micro-glandular arrangement by biopsy; tumor cells were round or polygonal,and cytoplasm was rich,eosinophilic and granular,and some parts were vesicular,nuclei were mostly located in the base and round and oval; a large number of eosinophils were found in the interstitial infiltrating,rich eosinophilic granules were also found in their cytoplasm,and nuclei were slightly atypia.Immunohistochemical staining showed that tumor cells were Cg A（-）,Ki-67（ index about 15%） and Syn（-）. Conclusion Pancreatic acinar cell carcinoma is rare. To avoid misdiagnosis it is essential to enhance awareness.