正常脑老化过程中海马头、体、尾部代谢物改变应用研究

Study on the metabolic changes in hippocampal head,body and tail during normal brain aging by means of 1H-MRS technique

目的：应用1 H－MRS技术，研究正常脑老化过程中双侧海马不同部位物质代谢的变化规律。方法对121名健康右利手志愿者，根据年龄分为青年组（20～44岁，47例）、中年组（45～59岁，40例）和老年组（60～79岁，40例）行颅脑MRI、MRS检查，自动测量并计算出海马区不同部位代谢物浓度比值NAA／Cr、Cho／Cr。分析不同性别、不同侧别、年龄组间各统计指标间的差异。结果双侧海马头部NAA／Cr比值在老年组与青年组、老年组与中年组间比较差异有统计学意义（ P ＜0 U．05）；双侧海马体1区、左侧海马体2区、左侧海马尾部NAA／Cr比值仅在青年组与老年组间差异有统计学意义（ P ＜0．05）；海马头、体（体1区、体2区）、尾部年龄组间Cho／Cr比值差异无统计学意义（ P ＞0．05）。双侧海马各部位NAA／Cr、Cho／Cr比值差异无统计学意义（ P ＞0．05）。海马头、体（体1区、体2区）、尾部NAA／Cr、Cho／Cr比值差异无统计学意义（ P ＞0．05）。结论双侧海马不同部位NAA／Cr比值存在年龄组间差异，Cho／Cr比值未见差异；双侧海马各部位NAA／Cr、Cho／Cr比值均不存在性别及侧别差异。

Objective To investigate the regulation of material metabolism changes in different regions of bilateral hippocampus during normal brain aging through proton magnetic resonance spectroscopy （1H-MRS） technique.Methods One hundred and twenty-one right handedness healthy volunteers were enrolled in the study ,according to their age who were divided into youth group （age range：20-44yr, n =47）,middle-aged group （age range：45-59yr, n =40）,older age group （age range：60-79yr, n =40）,all the volunteers were examined by MRI and MRS ,the concentration ratio of metabolite in different regions of bilateral hippocampus （ NAA/Cr and Cho/Cr ） was automatically measured .The differences of the parameters in different sex ,different side and different age groups were statistically analyzed .Results There was a significant difference in the concentration ratio of NAA/Cr in bilateral hippocampal head between older age group and youth group and between older age group and middle age group （ P 〈0.05）.There was a significant difference in the concentration ratio of NAA/Cr in bilateral hippocampal body-region 1,left hippocampal body-region 2 and left hippocampal body tail between older age group and youth group （ P 〈0.05）,however,there was no significant difference in the ratio of Cho /Cr in hippocampal head,body （region 1 and region 2） and tail among the three groups （ P 〉0.05）.There was no significant difference in the ratio of NAA/Cr,Cho/Cr in different regions of bilateral hippocampus （ P 〉0.05）.There was no significant difference in the ratio of NAA/Cr,Cho/Cr in hippocampal head ,body （region 1 and region 2） and tail among the three groups （ P 〉0.05）. Conclusion There is significant difference in the ratio of NAA/Cr in different regions of bilateral hippocampus among different age groups,howevere,there is no significant difference in the ratio of NAA/Cr.Moreover there is no significant difference in ratio of NAA/Cr,Cho/Cr in different regions of bilateral hippocampus between males and females and between left side and right side .