腹腔镜联合术后药物治疗对轻度子宫内膜异位症合并不孕患者的生育能力影响

Influence of Laparoscopic Surgery Combined with Postoperative Medical Therapy on the Reproductive Ability of Patients with Mild Endometriosis Complicated with Infertility

目的应用腹腔镜联合药物治疗轻度子宫内膜异位症合并不孕患者,探究其对患者生育能力的影响。方法将我院2013年8月至2014年8月接受随访的轻度子宫内膜异位症合并不孕患者108例作为研究对象,术后将之均分为亮丙瑞林组(A组)、孕三烯酮组(B组)和口服避孕药组(C组),对三组患者术后的妊娠、复发情况进行对比分析。结果A组妊娠率为83.3%,B组妊娠率为61.1%,C组妊娠率为55.6%,A组显著高于B组和C组(P<0.05),但B组与C组差异无统计学意义(P>0.05)。A组复发率为5.6%,B组复发率为25.0%,C组复发率为30.6%,A组显著低于B组和C组(P<0.05),但B组与C组差异无统计学意义(P>0.05)。结论应用腹腔镜联合亮丙瑞林治疗EMT合并不孕患者疗效最为显著,可有效降低复发率,具有临床推广的价值。

Objective To explore the effect of laparoscopic surgery combined with postoperative medical therapy on the reproductive ability of patients with mild endometriosis complicated with infertility. Methods 108 patients with mild endometriosis complicated with infertility in our hospital from August 2013 to August 2014 were selected as the research objects. All cases were divided into group A（leuprorelin group）, group B（gestrinone group） and group C（oral contraceptive group） according to the postoperative medical therapy, with36 cases in each group. The situations of pregnancy and recurrence after therapy of three groups were compared. Results The pregnancy rate of group A was 83.3%（30/36）, significantly higher than 61.1%（22/36） of group B and 55.6%（20/36） of group C（P〈0.05）, but there was no statistical difference between group B and group C（P〉0.05）. The recurrence rate of group A was 5.6%（2/36）, significantly lower than 25.0%（9/36） of group B and 30.6%（11/36） of group C（P〈0.05）, but there was no statistical difference between group B and group C（P〉0.05）. Conclusions Laparoscopic surgery combined with postoperative leuprorelin therapy has significant effect for the treatment of patients with mild endometriosis complicated with infertility, which can effectively reduce the recurrence rate.