地屈孕酮联合硫酸镁及间苯三酚治疗晚期先兆流产的临床效果观察

Observation on Clinical Effect of Dydrogesterone Combined with Magnesium Sulfate and Phloroglucinol for the Treatment of Advanced Threatened Abortion

目的探讨地屈孕酮联合硫酸镁及间苯三酚治疗晚期先兆流产的临床效果。方法将我院2012年8月至2014年8月收治的120例晚期先兆流产患者随机分为两组各60例,对照组单纯给予间苯三酚或硫酸镁进行治疗,观察组在对照组的基础上联合地屈孕酮进行治疗,对两组患者的临床症状缓解时间、药物不良反应、治疗效果等进行分析和比较。结果经治疗,观察组总有效率为93.33%,显著高于对照组的68.33%,两组患者治疗效果的差异具有统计学意义(P<0.05)。观察组患者临床症状消失时间平均为(0.68±0.27)d,对照组患者临床症状消失时间平均为(2.85±0.73)d,组间比较差异显著(P<0.05)。结论地屈孕酮联合硫酸镁及间苯三酚治疗晚期先兆流产效果显著,可显著降低患者临床症状缓解时间,改善预后,值得临床推广使用。

Objective To explore the clinical effect of dydrogesterone combined with magnesium sulfate and phloroglucinol for the treatment of advanced threatened abortion. Methods 120 cases of advanced threatened abortion were selected and randomly divided into two groups, with 60 cases in each group. The control group was given magnesium sulfate or phloroglucinol for treatment, while the observation group was given dydrogesterone additional. The time of symptoms relief, adverse reactions and curative effect were observed and compared between two groups. Results The total effective rate of observation group was 93.33%, significantly higher than 68.33% of control group（P0.05）. The time of symptoms relief of observation group was（0.68 ± 0.27） d, significantly shorter than（2.85 ± 0.73） d of control group（P0.05）. Conclusions Dydrogesterone combined with magnesium sulfate and phloroglucinol has significant effect in the treatment of advanced threatened abortion. It can decrease the time of symptoms relief and improve prognosis, which is worthy of clinical application.