螺内酯对慢性心力衰竭患者疗效的随访研究

Therapeutic Effect of Spironolactone in Patients with Chronic Heart Failure: A Follow-Up Study

目的观察螺内酯对慢性心力衰竭患者的临床疗效。方法收集就诊我院的慢性心力衰竭患者68例,按治疗方法不同分为对照组和治疗组。对照组34例给予常规抗心力衰竭药物治疗,治疗组34例在常规抗心力衰竭药物基础上加用螺内酯联合治疗。随访观察6个月,比较两组的临床效果。结果治疗半年后,两组的NYHA分级均较治疗前有所改善,差异有统计学意义(P<0.01);对照组LVEF、LVEDD及BNP水平与治疗前比较差异无统计学意义(P>0.05),但治疗组LVEF、LVEDD及BNP水平与治疗前比较差异具有统计学意义(P<0.01)。结论螺内酯治疗慢性心力衰竭可改善患者的心功能。

Objective To investigate the clinical efficacy of conventional drugs associated with spironolactone on patients with chronic heart failure（CHF）. Methods A total of 68 patients with CHF were divided into two groups. 34 cases of control group were treated with conventional drugs, while 34 cases of treatment group were treated with conventional drugs combined with spironolactone. The clinical effects of two groups were compared. Results After therapy, the NYHA class improved significantly in both group（P〈0.01）. The treatment group had significantly higher LVEF, and lower LVEDD and BNP level compared with baseline level（all P〈0.05）. Conclusions The conventional drugs associated with spironolactone can significantly improve cardiac function in patients with CHF.