卡维地洛对于慢性心力衰竭患者左房容积以及相关预后的影响观察

Observation on the Effect of Carvedilol on Left Atrial Volume and Prognosis in Patients with Chronic Heart Failure

目的分析卡维地洛对于慢性心力衰竭患者左房容积以及相关预后的影响。方法 2012年2月至2014年3月在我院住院治疗的慢性心力衰竭患者69例,随机分为卡维地洛组(35例)和对照组(34例)。观察分析卡维地洛组和对照组治疗3个月及6个月后的左房容积指数(LAVi),随访过程中的死亡率及再住院率。结果卡维地洛组治疗前及治疗3个月后的LAVi水平与对照组差异无统计学意义(P>0.05),而治疗6个月后LAVi水平显著低于对照组(P<0.05);卡维地洛组的死亡率及再住院率均显著低于对照组(P<0.05)。结论卡维地洛能够显著降低机体的LAVi水平,改善慢性心力衰竭患者的预后。

Objective To study the effect of carvedilol on left atrial volume and prognosis in patients with chronic heart failure.Methods Sixty-nine patients with chronic heart failure in our hospital from February 2012 to March 2014 were randomly divided into the carvedilol group and the control group. 34 cases of control group was given routine diuretic and ACEI therapy, while 35 cases of carvedilol group received carvedilol additional. The left atrial volume index（LAVi） at 3 months and 6 months of therapy, mortality and readmission rates during follow-up were observed and compared between two groups. Results There were no statistically significant differences in the LAVi before therapy and at 3 months of therapy between two groups（P〉0.05）, but after 6 months of therapy, the LAVi of carvedilol group was significantly lower than that of control group（P〈0.05）. The mortality rate and readmission rate of carvedilol group were significantly lower than those of control group（P〈0.05）. Conclusions Carvedilol can significantly reduce the LAVi level of patients with chronic heart failure,and improve patients＇ prognosis.