膀胱灌注化疗方法的改良和护理观察

Improvement and Nursing of Intravesical Chemotherapeutic Instillations

目的对比膀胱灌注化疗术改良前后的不良反应情况,比较其疗效,并探讨其术后护理措施。方法将60例来我院就诊的膀胱癌患者随机分为两组,改良前组在术后第一天,通过在膀胱内插入尿管,对其患者给予膀胱灌注(1次/周);改良后组使用静脉注射针头对病变部位用5%葡萄糖注射液溶解的吡柔比星注射液(25 mg)药液进行膀胱栓塞,并佐以相应的护理措施;两组患者复诊时间为1次/月,40周后再行肝癌切除术,以相关并发症、复发例数等为观察指标,对比两种治疗方法的不良情况发生率。结果改良后组和改良前组不良情况发生率分别为6.67%、53.33%;经比较,改良后组治疗效果明显优于改良前组(P<0.05)。结论将改良后的膀胱灌注化疗栓塞术应用于膀胱癌术后治疗,取得了很好的治疗效果,疗效优于改良前治疗方法,其不良反应少,具有安全性和可靠性,值得推广和应用。

Objective To explore the effect and adverse reactions of improved intravesical chemotherapeutic instillations, and explore the postoperative nursing methods. Methods Sixty patients with bladder cancer admitted to our hospital were randomly divided into modified group and traditional group, with 30 cases in each group. Patients in the traditional group were given intravesical instillation by inserting a catheter in the bladder at the first day after surgery. Patients in the modified group was given intravesical instillation with pirarubicin injection（25 mg） dissolving with 5% glucose injection, and related nursing intervention. The referral time was 1 time per month,and the treatment duration was 40 weeks. The clinical adverse situations of two groups were observed and compared. Results The incidence of adverse situations of modified group was 6.67%（2/30）, significantly lower than 53.33%（16/30） of traditional group, and the difference between two groups was statistically significant（P〈0.05）. Conclusions Modified intravesical chemotherapeutic instillation has significant effect in the postoperative therapy of bladder cancer. It has few adverse reactions, high safety and high reliability, which is worthy of wide promotion in clinic.