HB-H-6树脂的血液相容性研究

Study on blood compatibility of HB-H-6 resin

目的:用白蛋白预充技术改善HB-H-6树脂的血液相容性。方法:实验分为两部分,首先用HB-H-6树脂对血浆和全血进行体外动静态吸附实验,对比二者之间共有成分之间的差异;然后用白蛋白预充后的HB-H-6树脂和未预充的HB-H-6树脂对全血进行体外动静态吸附实验,对比未预充组与预充组血细胞与血小板的变化情况。结果:(1)血浆未预充组和全血未预充组的动静态吸附实验结果表明,未经处理的HB-H-6树脂对血浆和全血之间共有成分的吸附效果基本一致,灌流前后仅部分电解质有所变化。(2)动静态实验结果均表明,全血预充组中白细胞、红细胞和血小板的吸附率较全血未预充组均明显改善。结论:白蛋白预充技术改善了HB-H-6树脂的血液相容性,为临床上直接进行全血灌流提供了理论基础。

Objective：To improve the blood compatibility of HB-H-6 resin using prefilling the albumin. Methods： Dynamic and static adsorption experiments in vitro on plasma and whole blood with HB-H-6 resin were carried out, and the difference between the common compositions of plasma and whole blood were analyzed. Dynamic and static adsorption experiments in vitro on plasma and whole blood were carried out with the prefilled HB-H-6 resin be prefilled albumin and the unprefilled HB-H-6 resin, and the changes of the blood cells and platelets in the prefilled group and the unprefilled group were analyzed. Results： （1）The resuh of static and dynamic adsorption experiments in the prefilled group and the unprefilled group showed that the HB-H-6 resin untreated had the same the adsorption effect on the common composition of plasma and whole blood. After the perfusion, the protein and C3, C4 did not change significantly （P〉0.05）, and only part of the electrolyte changed,（2） The resuh of static and dynamic adsorption experiment showed, the adsorption rates of white blood cells, red blood cells and platelets in the prefilled group was lower than those in the unprefilled group. Conclusion： Prefilling the albumin improves the blood compatibility of HB-H-6 resin, provides a theoretical basis for whole blood perfusion in clinic.