普罗布考对急性动脉粥样硬化性脑梗死患者血清抵抗素及血脂水平的影响

Effect of probucoi on serum resistin and blood lipid profile in patients with acute cerebral infarction

目的探讨普罗布考对急性动脉粥样硬化性脑梗死患者血清抵抗素及血脂水平的影响。方法选取2012年4月至2013年4月在山东省高密市人民医院神经内科住院治疗的急性动脉粥样硬化性脑梗死患者102例，采用最小随机化法将入组者分为常规治疗组（51例）与联合治疗组（51例）。常规治疗组给予他汀类药物和抗血小板聚集药物。联合治疗组在常规治疗组基础上加用普罗布考。2组患者均在治疗前和治疗后14 d清晨采集空腹静脉血检测血清抵抗素、总胆固醇、三酰甘油、低密度脂蛋白胆固醇（LDLC）、高密度脂蛋白胆固醇水平,采用改良爱丁堡斯勘的那维亚卒中量表评价患者神经功能，比较2组患者治疗前和治疗后14 d的血清抵抗素、血脂水平及治疗前、治疗后7 d、治疗后14 d的神经功能评分。结果治疗后14 d，联合治疗组患者血清抵抗素水平[（17±9）mg/L]低于治疗前[（24±9）mg/L]和常规治疗组[（23±9）mg/L]；总胆固醇水平[（4.0±1.0）mmol/L]低于治疗前[（5.0±1.0）mmol/L]；LDLC水平[（2.3±0.8）mmol/L]低于治疗前[（3.3±0.8）mmol/L]和常规治疗组[（2.8±1.0）mmol/L]；神经功能评分[（8.0±3.2）分]低于治疗前[（25.0±2.9）分]和常规治疗组[（13.2±2.5）分]，差异均有统计学意义（均P＜0.05）。结论普罗布考联合他汀类药物治疗能够改善急性动脉粥样硬化性脑梗死患者血清抵抗素及血脂水平，提高患者近期疗效。

ObjectiveTo investigate the effect of probucol on the levels of serum resistin and blood lipid in patients with acute cerebral infarction. MethodsTotally 102 patients with acute cerebral infarction were collected from April 2012 to April 2013. The patients were randomly divided into two groups： conventional treatment group（51 cases） and combined treatment group （51 cases）. At the first day and after two weeks, the fasting venous blood samples were collected for measuring serum resistin and total cholesterol, triacylglycerol, low density lipoprotein cholesterol（LDLC）, high density lipoprotein cholesterol. At 7 d and 14 d, curative effects were evaluated by standard scale of clinical neurological deficit. ResultsAfter the treatment, the level of serum resistin in combined treatment group[（17±9）mg/L] was lower than that before treatment[（24±9）mg/L] and that in the conventional treatment group[（23±9）mg/L]; the level of total cholesterol[（4.0±1.0）mmol/L] was lower than that before treatment[（5.0±1.0）mmol/L]; the level of LDLC[（2.3±0.8）mmol/L] was lower than that before treatment[（3.3±0.8）mmol/L] and that in the conventional treatment group[（2.8±1.0）mmol/L]; neurological function score[（8.0±3.2）points] was below than that before treatment[（25.0±2.9）points] and that in routine treatment group[（13.2±2.5）points]; the differences were statistically significant （all P〈0.05）. ConclusionThe treatment of probucol combining with statins can improve the level of serum resistin and blood lipid profile of patients with acute cerebral infarction.